• Clinical Features and Risk Factors of Oedematous Mycobacterium ulcerans Lesions in an Australian Population: Beware Cellulitis in an Endemic Area

      O'Brien, Daniel P; Friedman, N Deborah; McDonald, Anthony; Callan, Peter; Hughes, Andrew; Athan, Eugene (Public Library of Science, 2014)
      Oedematous lesions are a less common but more severe form of Mycobacterium ulcerans disease. Misdiagnosis as bacterial cellulitis can lead to delays in treatment. We report the first comprehensive descriptions of the clinical features and risk factors of patients with oedematous disease from the Bellarine Peninsula of south-eastern Victoria, Australia.
    • Incidence, clinical spectrum, diagnostic features, treatment and predictors of paradoxical reactions during antibiotic treatment of Mycobacterium ulcerans infections

      O Brien, Daniel P; Robson, Mike; Friedman, N Deborah; Walton, Aaron; McDonald, Anthony; Callan, Peter; Hughes, Andrew; Rahdon, Richard; Athan, Eugene (BioMed Central Ltd., 2013-09-05)
      Paradoxical reactions from antibiotic treatment of Mycobacterium ulcerans have recently been recognized. Data is lacking regarding their incidence, clinical and diagnostic features, treatment, outcomes and risk factors in an Australian population.
    • Mycobacterium ulcerans treatment - can antibiotic duration be reduced in selected patients?

      Cowan, Raquel; Athan, Eugene; Friedman, N Deborah; Hughes, Andrew J; McDonald, Anthony; Callan, Peter; Fyfe, Janet; O'Brien, Daniel P (Public Library of Science, 2015-02-06)
      Mycobacterium ulcerans (M. ulcerans) is a necrotizing skin infection endemic to the Bellarine Peninsula, Australia. Current treatment recommendations include 8 weeks of combination antibiotics, with adjuvant surgery if necessary. However, antibiotic toxicity often results in early treatment cessation and local experience suggests that shorter antibiotic courses may be effective with concurrent surgery. We report the outcomes of patients in the Barwon Health M. ulcerans cohort who received shorter courses of antibiotic therapy than 8 weeks.