• Comparison of methods to correct survival estimates and survival regression analysis on a large HIV African cohort

      Henriques, Julie; Pujades-Rodriguez, Mar; McGuire, Megan; Szumilin, Elisabeth; Iwaz, Jean; Etard, Jean-François; Ecochard, René; Service de Biostatistique, Hospices Civils de Lyon, Lyon, France; Université de Lyon, Lyon, France; Université Lyon 1, Villeurbanne, France; Equipe Biostatistique-Santé, Centre National de la Recherche Scientifique-Unité Mixte de Recherche 5558 Laboratoire de Biométrie et Biologie Evolutive, Villeurbanne, France; Epicentre, Paris, France; Médecins Sans Frontières, Paris, France; Institut de Recherche pour le Développement-Université de Montpellier Unité Mixte Internationale 233 TransVIHMI, Montpellier, France (PLoS, 2012)
      The evaluation of HIV treatment programs is generally based on an estimation of survival among patients receiving antiretroviral treatment (ART). In large HIV programs, loss to follow-up (LFU) rates remain high despite active patient tracing, which is likely to bias survival estimates and survival regression analyses.
    • Estimation and Short-Term Prediction of the Course of the HIV Epidemic Using Demographic and Health Survey Methodology-Like Data

      Blaizot, Stéphanie; Riche, Benjamin; Maman, David; Mukui, Irene; Kirubi, Beatrice; Etard, Jean-François; Ecochard, René (Public Library of Science, 2015-06-19)
      Mathematical models have played important roles in the understanding of epidemics and in the study of the impacts of various behavioral or medical measures. However, modeling accurately the future spread of an epidemic requires context-specific parameters that are difficult to estimate because of lack of data. Our objective is to propose a methodology to estimate context-specific parameters using Demographic and Health Survey (DHS)-like data that can be used in mathematical modeling of short-term HIV spreading.
    • Impact of variability in adherence to HIV antiretroviral therapy on the immunovirological response and mortality

      Boussari, Olayidé; Subtil, Fabien; Genolini, Christophe; Bastard, Mathieu; Iwaz, Jean; Fonton, Noël; Etard, Jean-François; Ecochard, René (BioMed Central (Springer Science), 2015-02-05)
      Several previous studies have shown relationships between adherence to HIV antiretroviral therapy (ART) and the viral load, the CD4 cell count, or mortality. However, the impact of variability in adherence to ART on the immunovirological response does not seem to have been investigated yet.
    • Revisiting long-term adherence to highly active antiretroviral therapy in Senegal using latent class analysis.

      Bastard, Mathieu; Fall, Mame Basty Koita; Lanièce, Isabelle; Taverne, Bernard; Desclaux, Alice; Ecochard, René; Sow, Papa Salif; Delaporte, Eric; Etard, Jean-François; Hospices Civils de Lyon, Service de Biostatistique, Lyon, France. mathieu.bastard@epicentre.msf.org (Wolters Kluwer, 2011-05-01)
      Adherence is one of the main predictors of antiretroviral treatment success. A governmental initiative was launched in 1998 for HIV-infected patients in Senegal to provide access to highly active antiretroviral therapy.
    • Toxicity associated with stavudine dose reduction from 40 to 30 mg in first-line antiretroviral therapy.

      Pujades-Rodríguez, Mar; Dantony, Emmanuelle; Pinoges, Loretxu; Ecochard, René; Etard, Jean-François; Carrillo-Casas, Esther; Szumilin, Elisabeth; Clinical Research Department, Epicentre, Paris, France. mar.pujades@epicentre.msf.org (2011-11)
      To compare the incidence and timing of toxicity associated with the use of a reduced dose of stavudine from 40 to 30 mg in first-line antiretroviral therapy (ART) for HIV treatment and to investigate associated risk factors.
    • Women experience a better long-term immune recovery and a better survival on HAART in Lao People's Democratic Republic.

      Bastard, Mathieu; Soulinphumy, Khamphang; Phimmasone, Prasith; Saadani, Ahmed Hassani; Ciaffi, Laura; Communier, Arlette; Phimphachanh, Chansy; Ecochard, René; Etard, Jean-François; Epicentre, Paris, France. (BioMed Central, 2013-01-22)