• First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease

      Dörnemann, J; Burzio, C; Ronsse, A; Sprecher, A; De Clerck, H; Van Herp, M; Kolié, MC; Yosifiva, V; Caluwaerts, S; McElroy, AK; et al. (Oxford University Press, 2017-01-09)
      A neonate born to an Ebola virus-positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.