• Children with Moderate Acute Malnutrition Have Inflammation Not Explained by Maternal Reports of Illness and Clinical Symptoms: a Cross-Sectional Study in Burkina Faso

      Cichon, B; Fabiansen, C; Yameogo, C; Rytter, MJH; Ritz, C; Briend, A; Christensen, VB; Michaelsen, KF; Oummani, R; Filteau, S; et al. (BioMed Central, 2016-08-30)
      Morbidity plays an important role in the development of and recovery from malnutrition. Morbidity in children with moderate acute malnutrition (MAM) has not been described in detail and it is unclear how morbidity compares to serum levels of acute phase proteins (APPs) which indicate systemic inflammation and which can impede response to therapeutic nutritional interventions. The objective of this study was to describe morbidity in children with MAM and to assess to what extent maternally reported and clinically diagnosed morbidity explain the variation in APPs.
    • Deuterium Dilution Technique for Body Composition Assessment: Resolving Methodological Issues in Children with Moderate Acute Malnutrition

      Fabiansen, C; Yaméogo, CW; Devi, S; Friis, H; Kurpad, A; Wells, JC (Taylor and Francis, 2017-03-03)
      Childhood malnutrition is highly prevalent and associated with high mortality risk. In observational and interventional studies among malnourished children, body composition is increasingly recognised as a key outcome. The deuterium dilution technique has generated high-quality data on body composition in studies of infants and young children in several settings, but its feasibility and accuracy in children suffering from moderate acute malnutrition requires further study. Prior to a large nutritional intervention trial among children with moderate acute malnutrition, we conducted pilot work to develop and adapt the deuterium dilution technique. We refined procedures for administration of isotope doses and collection of saliva. Furthermore, we established that equilibration time in local context is 3 h. These findings and the resulting standard operating procedures are important to improve data quality when using the deuterium dilution technique in malnutrition studies in field conditions, and may encourage a wider use of isotope techniques.