• Using Simulation to Aid Trial Design: Ring-Vaccination Trials.

      Hitchings, MD; Grais, RFF; Lipsitch, M (Public Library of Science, 2017-03-22)
      The 2014-6 West African Ebola epidemic highlights the need for rigorous, rapid clinical trial methods for vaccines. A challenge for trial design is making sample size calculations based on incidence within the trial, total vaccine effect, and intracluster correlation, when these parameters are uncertain in the presence of indirect effects of vaccination.