• Feasibility of a mass vaccination campaign using a two-dose oral cholera vaccine in an urban cholera-endemic setting in Mozambique.

      Cavailler, P; Lucas, M; Perroud, V; McChesney, M; Ampuero, S; Guerin, P J; Legros, D; Nierle, T; Mahoudeau, C; Lab, B; et al. (2006-05-29)
      We conducted a study to assess the feasibility and the potential vaccine coverage of a mass vaccination campaign using a two-dose oral cholera vaccine in an urban endemic neighbourhood of Beira, Mozambique. The campaign was conducted from December 2003 to January 2004. Overall 98,152 doses were administered, and vaccine coverage of the target population was 58.6% and 53.6% for the first and second rounds, respectively. The direct cost of the campaign, which excludes the price of the vaccine, amounted to slightly over 90,000 dollars, resulting in the cost per fully vaccinated person of 2.09 dollars, which is relatively high. However, in endemic settings where outbreaks are likely to occur, integrating cholera vaccination into the routine activities of the public health system could reduce such costs.
    • Feasibility of Mass Vaccination Campaign with Oral Cholera Vaccines in Response to an Outbreak in Guinea

      Ciglenecki, I; Sakoba, K; Luquero, F J; Heile, M; Itama, C; Mengel, M; Grais, RF; Verhoustraeten, F; Legros, D (2013-09-10)
    • Mass Vaccination with a Two-Dose Oral Cholera Vaccine in a Refugee Camp.

      Legros, D; Paquet, C; Perea, W; Marty, I; Mugisha, N K; Royer, H; Neira, M; Ivanoff, B; Epicentre, Kampala, Uganda. (Published by WHO, 1999)
      In refugee settings, the use of cholera vaccines is controversial since a mass vaccination campaign might disrupt other priority interventions. We therefore conducted a study to assess the feasibility of such a campaign using a two-dose oral cholera vaccine in a refugee camp. The campaign, using killed whole-cell/recombinant B-subunit cholera vaccine, was carried out in October 1997 among 44,000 south Sudanese refugees in Uganda. Outcome variables included the number of doses administered, the drop-out rate between the two rounds, the proportion of vaccine wasted, the speed of administration, the cost of the campaign, and the vaccine coverage. Overall, 63,220 doses of vaccine were administered. At best, 200 vaccine doses were administered per vaccination site and per hour. The direct cost of the campaign amounted to US$ 14,655, not including the vaccine itself. Vaccine coverage, based on vaccination cards, was 83.0% and 75.9% for the first and second rounds, respectively. Mass vaccination of a large refugee population with an oral cholera vaccine therefore proved to be feasible. A pre-emptive vaccination strategy could be considered in stable refugee settings and in urban slums in high-risk areas. However, the potential cost of the vaccine and the absence of quickly accessible stockpiles are major drawbacks for its large-scale use.
    • Post-licensure deployment of oral cholera vaccines: a systematic review

      Martin, S; Lopez, A L; Bellos, A; Deen, J; Ali, M; Alberti, K; Anh, D D; Costa, A; Grais, RF; Legros, D; et al. (World Health Organization, 2014-12-01)
      To describe and analyse the characteristics of oral cholera vaccination campaigns; including location, target population, logistics, vaccine coverage and delivery costs.
    • Use of Vibrio cholerae Vaccine in an Outbreak in Guinea

      Luquero, F J; Grout, L; Ciglenecki, I; Sakoba, K; Traore, B; Heile, M; Diallo, A A; Itama, C; Page, A-L; Quilici, M-L; et al. (Massachusetts Medical Society, 2014-05-29)