• Neighborhood-Targeted and Case-Triggered Use of a Single Dose of Oral Cholera Vaccine in an Urban Setting: Feasibility and Vaccine Coverage

      Parker, L; Rumunu, J; Jamet, C; Kenyi, Y; Lino, R; Wamala, J; Mpairwe, A; Muller, V; Llosa, A; Uzzeni, F; et al. (Public Library of Science, 2017-06-08)
      In June 2015, a cholera outbreak was declared in Juba, South Sudan. In addition to standard outbreak control measures, oral cholera vaccine (OCV) was proposed. As sufficient doses to cover the at-risk population were unavailable, a campaign using half the standard dosing regimen (one-dose) targeted high-risk neighborhoods and groups including neighbors of suspected cases. Here we report the operational details of this first public health use of a single-dose regimen of OCV and illustrate the feasibility of conducting highly targeted vaccination campaigns in an urban area.
    • Time is (still) of the essence: quantifying the impact of emergency meningitis vaccination response in Katsina State, Nigeria.

      Ferrari, M J; Fermon, F; Nackers, F; Llosa, A; Magone, C; Grais, RF (Oxford University Press, 2014-09-05)
      In 2009, a large meningitis A epidemic affected a broad region of northern Nigeria and southern Niger, resulting in more than 75 000 cases and 4000 deaths. In collaboration with state and federal agencies, Médecins Sans Frontières (MSF) intervened with a large-scale vaccination campaign using polysaccharide vaccine. Here the authors analyze the impact (cases averted) of the vaccination response as a function of the timing and coverage achieved.