Show simple item record

dc.contributor.authorStepniewska, Kasia
dc.contributor.authorAshley, Elizabeth
dc.contributor.authorLee, Sue J
dc.contributor.authorAnstey, Nicholas
dc.contributor.authorBarnes, Karen I
dc.contributor.authorBinh, Tran Quang
dc.contributor.authorD'Alessandro, Umberto
dc.contributor.authorDay, Nicholas P J
dc.contributor.authorde Vries, Peter J
dc.contributor.authorDorsey, Grant
dc.contributor.authorGuthmann, Jean-Paul
dc.contributor.authorMayxay, Mayfong
dc.contributor.authorNewton, Paul N
dc.contributor.authorOlliaro, Piero
dc.contributor.authorOsorio, Lyda
dc.contributor.authorPrice, Ric N
dc.contributor.authorRowland, Mark
dc.contributor.authorSmithuis, Frank
dc.contributor.authorTaylor, Walter R J
dc.contributor.authorNosten, François
dc.contributor.authorWhite, Nicholas J
dc.date.accessioned2010-10-08T14:56:20Z
dc.date.available2010-10-08T14:56:20Z
dc.date.issued2010-01-19
dc.identifier.citationJ Infect Dis 2010;201(4):570-9en
dc.identifier.issn1537-6613
dc.identifier.pmid20085495
dc.identifier.doi10.1086/650301
dc.identifier.urihttp://hdl.handle.net/10144/112694
dc.description.abstractParasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n=14,539), moderate (n=2077), and high (n=2083) levels of malaria transmission across the world were analyzed to determine the factors that affect clearance rates and identify a simple in vivo screening measure for artemisinin resistance. The main factor affecting parasite clearance time was parasite density on admission. Clearance rates were faster in high-transmission settings and with more effective partner drugs in artemisinin-based combination treatments (ACTs). The result of the malaria blood smear on day 3 (72 h) was a good predictor of subsequent treatment failure and provides a simple screening measure for artemisinin resistance. Artemisinin resistance is highly unlikely if the proportion of patients with parasite densities of <100,000 parasites/microL given the currently recommended 3-day ACT who have a positive smear result on day 3 is <3%; that is, for n patients the observed number with a positive smear result on day 3 does not exceed (n + 60)/24.
dc.language.isoenen
dc.rightsPublished by Infectious Diseases Society of America Archived on this site with permission and copyright 2010 by the Infectious Diseases Society of America, [url]http://www.journals.uchicago.edu/toc/jid[/url]en
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshAntimalarialsen
dc.subject.meshArtemisininsen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshDrug Resistanceen
dc.subject.meshEndemic Diseasesen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshKaplan-Meiers Estimateen
dc.subject.meshMalaria, Falciparumen
dc.subject.meshMiddle Ageden
dc.subject.meshParasitemiaen
dc.subject.meshPlasmodium falciparumen
dc.subject.meshRecurrenceen
dc.titleIn vivo parasitological measures of artemisinin susceptibilityen
dc.typeArticleen
dc.contributor.departmentMahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand; Shoklo Malaria Research Unit, Mae Sot, Thailand; Menzies School of Health Research and Royal Darwin Hospital, Darwin, Australia; Division of Clinical Pharmacology, Department of Medicine, Universityen
dc.identifier.journalThe Journal of Infectious Diseasesen
refterms.dateFOA2019-03-04T08:22:10Z
html.description.abstractParasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n=14,539), moderate (n=2077), and high (n=2083) levels of malaria transmission across the world were analyzed to determine the factors that affect clearance rates and identify a simple in vivo screening measure for artemisinin resistance. The main factor affecting parasite clearance time was parasite density on admission. Clearance rates were faster in high-transmission settings and with more effective partner drugs in artemisinin-based combination treatments (ACTs). The result of the malaria blood smear on day 3 (72 h) was a good predictor of subsequent treatment failure and provides a simple screening measure for artemisinin resistance. Artemisinin resistance is highly unlikely if the proportion of patients with parasite densities of <100,000 parasites/microL given the currently recommended 3-day ACT who have a positive smear result on day 3 is <3%; that is, for n patients the observed number with a positive smear result on day 3 does not exceed (n + 60)/24.


Files in this item

Thumbnail
Name:
100119_Stepniewska_artemisinin ...
Size:
380.6Kb
Format:
PDF
Description:
Main article

This item appears in the following Collection(s)

Show simple item record