In vivo parasitological measures of artemisinin susceptibility
dc.contributor.author | Stepniewska, Kasia | |
dc.contributor.author | Ashley, Elizabeth | |
dc.contributor.author | Lee, Sue J | |
dc.contributor.author | Anstey, Nicholas | |
dc.contributor.author | Barnes, Karen I | |
dc.contributor.author | Binh, Tran Quang | |
dc.contributor.author | D'Alessandro, Umberto | |
dc.contributor.author | Day, Nicholas P J | |
dc.contributor.author | de Vries, Peter J | |
dc.contributor.author | Dorsey, Grant | |
dc.contributor.author | Guthmann, Jean-Paul | |
dc.contributor.author | Mayxay, Mayfong | |
dc.contributor.author | Newton, Paul N | |
dc.contributor.author | Olliaro, Piero | |
dc.contributor.author | Osorio, Lyda | |
dc.contributor.author | Price, Ric N | |
dc.contributor.author | Rowland, Mark | |
dc.contributor.author | Smithuis, Frank | |
dc.contributor.author | Taylor, Walter R J | |
dc.contributor.author | Nosten, François | |
dc.contributor.author | White, Nicholas J | |
dc.date.accessioned | 2010-10-08T14:56:20Z | |
dc.date.available | 2010-10-08T14:56:20Z | |
dc.date.issued | 2010-01-19 | |
dc.identifier.citation | J Infect Dis 2010;201(4):570-9 | en |
dc.identifier.issn | 1537-6613 | |
dc.identifier.pmid | 20085495 | |
dc.identifier.doi | 10.1086/650301 | |
dc.identifier.uri | http://hdl.handle.net/10144/112694 | |
dc.description.abstract | Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n=14,539), moderate (n=2077), and high (n=2083) levels of malaria transmission across the world were analyzed to determine the factors that affect clearance rates and identify a simple in vivo screening measure for artemisinin resistance. The main factor affecting parasite clearance time was parasite density on admission. Clearance rates were faster in high-transmission settings and with more effective partner drugs in artemisinin-based combination treatments (ACTs). The result of the malaria blood smear on day 3 (72 h) was a good predictor of subsequent treatment failure and provides a simple screening measure for artemisinin resistance. Artemisinin resistance is highly unlikely if the proportion of patients with parasite densities of <100,000 parasites/microL given the currently recommended 3-day ACT who have a positive smear result on day 3 is <3%; that is, for n patients the observed number with a positive smear result on day 3 does not exceed (n + 60)/24. | |
dc.language.iso | en | en |
dc.rights | Published by Infectious Diseases Society of America Archived on this site with permission and copyright 2010 by the Infectious Diseases Society of America, [url]http://www.journals.uchicago.edu/toc/jid[/url] | en |
dc.subject.mesh | Adolescent | en |
dc.subject.mesh | Adult | en |
dc.subject.mesh | Aged | en |
dc.subject.mesh | Aged, 80 and over | en |
dc.subject.mesh | Antimalarials | en |
dc.subject.mesh | Artemisinins | en |
dc.subject.mesh | Child | en |
dc.subject.mesh | Child, Preschool | en |
dc.subject.mesh | Drug Resistance | en |
dc.subject.mesh | Endemic Diseases | en |
dc.subject.mesh | Humans | en |
dc.subject.mesh | Infant | en |
dc.subject.mesh | Kaplan-Meiers Estimate | en |
dc.subject.mesh | Malaria, Falciparum | en |
dc.subject.mesh | Middle Aged | en |
dc.subject.mesh | Parasitemia | en |
dc.subject.mesh | Plasmodium falciparum | en |
dc.subject.mesh | Recurrence | en |
dc.title | In vivo parasitological measures of artemisinin susceptibility | en |
dc.type | Article | en |
dc.contributor.department | Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand; Shoklo Malaria Research Unit, Mae Sot, Thailand; Menzies School of Health Research and Royal Darwin Hospital, Darwin, Australia; Division of Clinical Pharmacology, Department of Medicine, University | en |
dc.identifier.journal | The Journal of Infectious Diseases | en |
refterms.dateFOA | 2019-03-04T08:22:10Z | |
html.description.abstract | Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n=14,539), moderate (n=2077), and high (n=2083) levels of malaria transmission across the world were analyzed to determine the factors that affect clearance rates and identify a simple in vivo screening measure for artemisinin resistance. The main factor affecting parasite clearance time was parasite density on admission. Clearance rates were faster in high-transmission settings and with more effective partner drugs in artemisinin-based combination treatments (ACTs). The result of the malaria blood smear on day 3 (72 h) was a good predictor of subsequent treatment failure and provides a simple screening measure for artemisinin resistance. Artemisinin resistance is highly unlikely if the proportion of patients with parasite densities of <100,000 parasites/microL given the currently recommended 3-day ACT who have a positive smear result on day 3 is <3%; that is, for n patients the observed number with a positive smear result on day 3 does not exceed (n + 60)/24. |