Risk factors for visceral leishmaniasis in a new epidemic site in Amhara Region, Ethiopia
Authors
Bashaye, SeifeNombela, Nohelly
Argaw, Daniel
Mulugeta, Abate
Herrero, Merce
Nieto, Javier
Chicharro, Carmen
Cañavate, Carmen
Aparicio, Pilar
Vélez, Iván Darío
Alvar, Jorge
Bern, Caryn
Affiliation
Malaria & Other Vector Borne Diseases, Prevention and Control Program, Ministry of Health, Addis Ababa, Ethiopia; Department for the Control of Neglected Tropical Diseases (HTM/NTD/IDM), Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland; Disease Prevention and Control Programmes, World Health Organization, Ethiopia; Médecins sans Frontières, Greece, Ethiopia; WHO Collaborating Center for Leishmaniasis, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain; Universidad de Antioquia, Medellin, Colombia; Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GeorgiaIssue Date
2009-07-01
Metadata
Show full item recordAbstract
We conducted a case-control study to evaluate risk factors for visceral leishmaniasis during an epidemic in a previously unaffected district of Ethiopia. We also collected blood and bone marrow specimens from dogs in the outbreak villages. In multivariable analyses of 171 matched case-control pairs, dog ownership, sleeping under an acacia tree during the day, and habitually sleeping outside at night were associated with significantly increased risk. Specimens from 7 (3.8%) dogs were positive by immunofluorescent antibody test (IFAT) and both enzyme-linked immunosorbent assays (ELISAs), whereas Leishmania DNA was detected in 5 (2.8%) bone marrow aspirates (from 3 seropositive and 2 seronegative dogs). Insecticide-treated nets may only protect a portion of those at risk. Further research on the vectors, the role of the dog in the transmission cycle, and the effect of candidate interventions are needed to design the best strategy for control.PubMed ID
19556563Additional Links
http://www.ajtmh.org/cgi/content/full/81/1/34Type
ArticleLanguage
enISSN
1476-1645Collections
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