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    Jan 26, 2021
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    Human African trypanosomiasis

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    091014_Brun_HAT_Lancet-2009-37 ...
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    Authors
    Brun, R
    Blum, J
    Chappuis, F
    Burri, C
    Affiliation
    Swiss Tropical Institute, Basel, Switzerland; Geneva University Hospitals, University of Geneva, Switzerland; Médecins Sans Frontières, Geneva, Switzerland
    Issue Date
    2009-10-14
    Submitted date
    2010-10-15
    
    Metadata
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    Journal
    Lancet
    Abstract
    Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies. Almost all cases are due to Trypanosoma brucei gambiense, which is indigenous to west and central Africa. Prevalence is strongly dependent on control measures, which are often neglected during periods of political instability, thus leading to resurgence. With fewer than 12 000 cases of this disabling and fatal disease reported per year, trypanosomiasis belongs to the most neglected tropical diseases. The clinical presentation is complex, and diagnosis and treatment difficult. The available drugs are old, complicated to administer, and can cause severe adverse reactions. New diagnostic methods and safe and effective drugs are urgently needed. Vector control, to reduce the number of flies in existing foci, needs to be organised on a pan-African basis. WHO has stated that if national control programmes, international organisations, research institutes, and philanthropic partners engage in concerted action, elimination of this disease might even be possible.
    URI
    http://hdl.handle.net/10144/114145
    DOI
    10.1016/S0140-6736(09)60829-1
    PubMed ID
    19833383
    Additional Links
    http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)60829-1/fulltext
    Type
    Article
    Language
    en
    ISSN
    1474-547X
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0140-6736(09)60829-1
    Scopus Count
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    Trypanosomiasis/Sleeping Sickness

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