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dc.contributor.authorBrun, R*
dc.contributor.authorBlum, J*
dc.contributor.authorChappuis, F*
dc.contributor.authorBurri, C*
dc.date.accessioned2010-10-29T15:18:48Z
dc.date.available2010-10-29T15:18:48Z
dc.date.issued2009-10-14
dc.date.submitted2010-10-15
dc.identifier.citationLancet 2010;375(9709):148-59en
dc.identifier.issn1474-547X
dc.identifier.pmid19833383
dc.identifier.doi10.1016/S0140-6736(09)60829-1
dc.identifier.urihttp://hdl.handle.net/10144/114145
dc.description.abstractHuman African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies. Almost all cases are due to Trypanosoma brucei gambiense, which is indigenous to west and central Africa. Prevalence is strongly dependent on control measures, which are often neglected during periods of political instability, thus leading to resurgence. With fewer than 12 000 cases of this disabling and fatal disease reported per year, trypanosomiasis belongs to the most neglected tropical diseases. The clinical presentation is complex, and diagnosis and treatment difficult. The available drugs are old, complicated to administer, and can cause severe adverse reactions. New diagnostic methods and safe and effective drugs are urgently needed. Vector control, to reduce the number of flies in existing foci, needs to be organised on a pan-African basis. WHO has stated that if national control programmes, international organisations, research institutes, and philanthropic partners engage in concerted action, elimination of this disease might even be possible.
dc.language.isoenen
dc.relation.urlhttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)60829-1/fulltexten
dc.rightsReproduced on this site with permission of Elsevier Ltd. Please see [url]http://www.thelancet.com/[/url] for further relevant comment.en
dc.subject.meshAfricaen
dc.subject.meshAnimalsen
dc.subject.meshBiomedical Researchen
dc.subject.meshCommunicable Disease Controlen
dc.subject.meshEflornithineen
dc.subject.meshEndemic Diseasesen
dc.subject.meshHumansen
dc.subject.meshIncidenceen
dc.subject.meshInsect Bites and Stingsen
dc.subject.meshInsect Vectorsen
dc.subject.meshMelarsoprolen
dc.subject.meshPentamidineen
dc.subject.meshSuraminen
dc.subject.meshTrypanocidal Agentsen
dc.subject.meshTrypanosoma brucei gambienseen
dc.subject.meshTrypanosomiasis, Africanen
dc.subject.meshTsetse Fliesen
dc.subject.meshVariant Surface Glycoproteins, Trypanosomaen
dc.titleHuman African trypanosomiasisen
dc.typeArticleen
dc.contributor.departmentSwiss Tropical Institute, Basel, Switzerland; Geneva University Hospitals, University of Geneva, Switzerland; Médecins Sans Frontières, Geneva, Switzerlanden
dc.identifier.journalLanceten
refterms.dateFOA2019-03-04T08:28:23Z
html.description.abstractHuman African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies. Almost all cases are due to Trypanosoma brucei gambiense, which is indigenous to west and central Africa. Prevalence is strongly dependent on control measures, which are often neglected during periods of political instability, thus leading to resurgence. With fewer than 12 000 cases of this disabling and fatal disease reported per year, trypanosomiasis belongs to the most neglected tropical diseases. The clinical presentation is complex, and diagnosis and treatment difficult. The available drugs are old, complicated to administer, and can cause severe adverse reactions. New diagnostic methods and safe and effective drugs are urgently needed. Vector control, to reduce the number of flies in existing foci, needs to be organised on a pan-African basis. WHO has stated that if national control programmes, international organisations, research institutes, and philanthropic partners engage in concerted action, elimination of this disease might even be possible.


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