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    Jan 23, 2021
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    Prevalence, risk factors, and impact on outcome of cytomegalovirus replication in serum of Cambodian HIV-infected patients (2004-2007)

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    Authors
    Micol, Romain
    Buchy, Philippe
    Guerrier, Gilles
    Duong, Veasna
    Ferradini, Laurent
    Dousset, Jean-Philippe
    Guerin, Philippe J
    Balkan, Suna
    Galimand, Julie
    Chanroeun, Hak
    Lortholary, Olivier
    Rouzioux, Christine
    Fontanet, Arnaud
    Leruez-Ville, Marianne
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    Affiliation
    Unité d'Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France; Laboratoire de Virologie, Universite Rene Descartes, Hopital Necker-Enfants Malades, Paris, France; Unite de virologie, Institut Pasteur du Cambodge, Phnom Penh, Cambodia; Medecins Sans Frontieres, Hopital Prea Bath Norodom Sihanouk, Phnom Penh, Cambodia; Medecins Du Monde, Hopital Kosamak, Phnom Penh, Cambodia; Epicentre, Paris, France; Medecins Sans Frontieres, Paris, France; Service des Maladies Infectieuses et Tropicales, Hopital Calmette, Phnom Penh, Cambodia; Universite Rene Descartes, Service des Maladies Infectieuses et Tropicales, Centre d’Infectiologie Necker–Pasteur, Hopital Necker–Enfants Malades, Paris, France
    Issue Date
    2009-08-01
    Submitted date
    2010-10-15
    
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    Journal
    Journal of Acquired Immune Deficiency Syndromes (1999)
    Abstract
    BACKGROUND: In developing countries, the study of cytomegalovirus (CMV) coinfection in HIV-infected patients remains neglected. Quantitative CMV polymerase chain reaction (PCR) is the gold standard diagnostic tool for analyzing serum CMV replication and for predicting CMV disease. We estimated the prevalence of replicating CMV in sera of newly diagnosed HIV-infected Cambodian patients and examined its impact on mortality. METHODS: This cohort study was based on 2 highly active antiretroviral therapy treatment programs in Cambodia between 2004 and 2007. Quantitative CMV PCR was performed on baseline serum samples of 377 HIV-infected patients. RESULTS: The prevalence of serum CMV DNA was 55.2% (150 of 272) in patients with CD4 count <100/mm. In multivariate analysis, hemoglobin <9 g/dL, CD4 count <100/mm, and Karnofsky index <50 were independently associated with positive serum CMV DNA at baseline. During a 3-year follow-up period, CMV viral load >or=3.1 log10 copies per milliliter was significantly associated with death independently of CD4 count, other opportunistic infections, and highly active antiretroviral therapy. CONCLUSIONS: As in industrialized countries, serum CMV replication is highly prevalent among HIV-infected Cambodian patients and is associated with increased mortality. This underscores the importance of diagnostic CMV infection by PCR in sera of HIV-infected patients with CD4 count <100/mm and treating this opportunistic infection to reduce its associated mortality.
    URI
    http://hdl.handle.net/10144/115226
    DOI
    10.1097/QAI.0b013e3181a254c2
    PubMed ID
    19421071
    Additional Links
    http://journals.lww.com/jaids/pages/articleviewer.aspx?year=2009&issue=08010&article=00017&type=abstract
    Type
    Article
    Language
    en
    ISSN
    1525-4135
    ae974a485f413a2113503eed53cd6c53
    10.1097/QAI.0b013e3181a254c2
    Scopus Count
    Collections
    HIV/AIDS

    entitlement

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