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    Jan 20, 2021
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    Treatment and seroconversion in a cohort of children suffering from recent chronic Chagas infection in Yoro, Honduras

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    Authors
    Escribà, Josep M
    Ponce, Elisa
    Romero, Alberto de Dios
    Viñas, Pedro Albajar
    Marchiol, Andrea
    Bassets, Glòria
    Palma, Pedro Pablo
    Lima, M Angeles
    Zúniga, Concepción
    Ponce, Carlos
    Affiliation
    Médécins Sans Frontières, Barcelona, Spain; Central Reference Laboratory for Chagas Disease and Leishmaniasis; National Chagas Disease Prevention and Control Program, Secretariat of Health, Tegucigalpa, Honduras; Laboratório de Doenças Parasitarias - Medicina Tropical, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil
    Issue Date
    2009-11-01
    
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    Journal
    Memórias do Instituto Oswaldo Cruz
    Abstract
    Between 1999-2002, Médécins Sans Frontières-Spain implemented a project seeking to determine the efficacy and safety of benznidazole in the treatment of recent chronic Chagas disease in a cohort of seropositive children in the Yoro Department, Honduras. A total of 24,471 children were screened for Trypanosoma cruzi IgG antibodies through conventional enzyme-linked immunosorbent assays (ELISA) on filter paper. Recombinant ELISA (0.93% seroprevalence) showed 256 initially reactive cases, including 232 confirmed positive cases. Of these, 231 individuals were treated with benznidazole (7.5 mg/kg/day) for 60 days and were followed with a strict weekly medical control and follow-up protocol. At the end of the project, 229 patients were examined by the Honduras Secretariat of Health for post-treatment serological assessments; 88.2% seroconverted after 18 months and 93.9% seroconverted after three years. No differences were found in the seroconversion rates according to age or sex. Most of the side effects of the treatment were minor. These results support the argument that in areas where T. cruzi I is predominant and in areas affected by T. cruzi II, when vector transmission has been interrupted, Chagas disease diagnosis and treatment are feasible, necessary and ethically indisputable.
    URI
    http://hdl.handle.net/10144/116331
    PubMed ID
    20027465
    Additional Links
    http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000700008&lng=en&nrm=iso&tlng=en
    Type
    Article
    Language
    en
    ISSN
    1678-8060
    Collections
    Other Diseases

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