Marburg hemorrhagic fever in Durba and Watsa, Democratic Republic of the Congo: clinical documentation, features of illness, and treatment
Van Kerkhove, Maria D
Bausch, Daniel G
Rollin, Pierre E
AffiliationInstitute of Tropical Medicine Antwerp, Antwerp, Belgium; University of Antwerp, Antwerp, Belgium; Medecins Sans Frontieres, Brussels, Belgium; Okimo Hospital, Watsa, Democratic Republic of the Congo; Ministry of Health, Kinshasa, Democratic Republic of the Congo; World Health Organization, Kinshasa, Democratic Republic of the Congo; Institut National de Recherche Biomedicale, Kinshasa, Democratic Republic of the Congo; London School of Hygiene and Tropical Medicine, London, United Kingdom; Centers for Disease Control and Prevention, Atlanta, Georgia; Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Medecins Sans Frontieres, Amsterdam, The Netherlands; World Health Organization, Geneva, Switzerland
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AbstractThe objective of the present study was to describe day of onset and duration of symptoms of Marburg hemorrhagic fever (MHF), to summarize the treatments applied, and to assess the quality of clinical documentation. Surveillance and clinical records of 77 patients with MHF cases were reviewed. Initial symptoms included fever, headache, general pain, nausea, vomiting, and anorexia (median day of onset, day 1-2), followed by hemorrhagic manifestations (day 5-8+), and terminal symptoms included confusion, agitation, coma, anuria, and shock. Treatment in isolation wards was acceptable, but the quality of clinical documentation was unsatisfactory. Improved clinical documentation is necessary for a basic evaluation of supportive treatment.
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