• Cryptococcal meningitis in HIV-infected patients: a longitudinal study in Cambodia.

      Espié, Emmanuelle; Pinoges, Loretxu; Balkan, Suna; Chanchhaya, Ngeth; Molfino, Lucas; Narom, Prak; Pujades-Rodríguez, Mar; Epicentre, Médecins Sans Frontières, 8 rue Saint Sabin, Paris, France. (2010-11)
      To describe the frequency of diagnosis of cryptococcosis among HIV-infected patients in Phnom Penh, Cambodia, at programme entry, to investigate associated risk factors, and to determine the incidence of cryptococcal meningitis.
    • Evaluation of a 5-year programme to prevent mother-to-child transmission of HIV infection in Northern Uganda

      Ahoua, Laurence; Ayikoru, Harriet; Gnauck, Katherine; Odaru, Grace; Odar, Emmanuel; Ondoa-Onama, Christine; Pinoges, Loretxu; Balkan, Suna; Olson, David; Pujades-Rodríguez, Mar; et al. (2010-07-13)
      Prevention of mother-to-child transmission (PMTCT) is essential in HIV/AIDS control. We analysed 2000-05 data from mother-infant pairs in our PMTCT programme in rural Uganda, examining programme utilization and outcomes, HIV transmission rates and predictors of death or loss to follow-up (LFU). Out of 19,017 women, 1,037 (5.5%) attending antenatal care services tested HIV positive. Of these, 517 (50%) enrolled in the PMTCT programme and gave birth to 567 infants. Before tracing, 303 (53%) mother-infant pairs were LFU. Reasons for dropout were infant death and lack of understanding of importance of follow-up. Risk of death or LFU was higher among infants with no or incomplete intrapartum prophylaxis (OR = 1.90, 95% CI 1.07-3.36) and of weaning age <6 months (OR 2.55, 95% CI 1.42-4.58), and lower in infants with diagnosed acute illness (OR 0.30, 95% CI 0.16-0.55). Mother-to-child HIV cumulative transmission rate was 8.3%, and 15.5% when HIV-related deaths were considered. Improved tracking of HIV-exposed infants is needed in PMTCT programmes where access to early infant diagnosis is still limited.
    • Gender differences in immune reconstitution: a multicentric cohort analysis in sub-saharan Africa

      Maman, David; Pujades-Rodriguez, Mar; Subtil, Fabien; Pinoges, Loretxu; McGuire, Megan; Ecochard, Rene; Etard, Jean-François; Epicentre, Médecins Sans Frontières, Paris, France; Hospices Civils de Lyon, Service de Biostatistique, Lyon, France; TransVIHMI, Montpellier, France; Université de Lyon, Lyon, France; Université Lyon I, Villeurbanne, France; 6 Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique Santé, Pierre-Bénite, France (Public Library of Science (PLoS), 2012-02-17)
      In sub-Saharan Africa, men living with HIV often start ART at more advanced stages of disease and have higher early mortality than women. We investigated gender difference in long-term immune reconstitution.
    • Immunovirological response to combined antiretroviral therapy and drug resistance patterns in children: 1- and 2-year outcomes in rural Uganda.

      Ahoua, Laurence; Guenther, Gunar; Rouzioux, Christine; Pinoges, Loretxu; Anguzu, Paul; Taburet, Anne-Marie; Balkan, Suna; Olson, David M; Olaro, Charles; Pujades-Rodríguez, Mar; et al. (BioMed Central, 2011-07-26)
      Children living with HIV continue to be in urgent need of combined antiretroviral therapy (ART). Strategies to scale up and improve pediatric HIV care in resource-poor regions, especially in sub-Saharan Africa, require further research from these settings. We describe treatment outcomes in children treated in rural Uganda after 1 and 2 years of ART start.
    • Risk factors and mortality associated with resistance to first line antiretroviral therapy: multicentric cross-sectional and longitudinal analyses

      Pinoges, Loretxu; Schramm, Birgit; Poulet, Elisabeth; Balkan, Suna; Szumilin, Elisabeth; Ferreyra, Cecilia; Pujades-Rodríguez, M (Lippincott Williams & Wilkins, 2015-01-12)
      Understanding the factors associated with HIV drug resistance development and subsequent mortality is important to improve clinical patient management.
    • Timeliness of Clinic Attendance is a good predictor of Virological Response and Resistance to Antiretroviral drugs in HIV-infected patients

      Bastard, Mathieu; Pinoges, Loretxu; Balkan, Suna; Szumilin, Elisabeth; Ferreyra, Cecilia; Pujades-Rodriguez, Mar; Epicentre, Paris, France. mathieu.bastard@geneva.msf.org (2012-11-07)
      Ensuring long-term adherence to therapy is essential for the success of HIV treatment. As access to viral load monitoring and genotyping is poor in resource-limited settings, a simple tool to monitor adherence is needed. We assessed the relationship between an indicator based on timeliness of clinic attendance and virological response and HIV drug resistance.
    • Toxicity associated with stavudine dose reduction from 40 to 30 mg in first-line antiretroviral therapy.

      Pujades-Rodríguez, Mar; Dantony, Emmanuelle; Pinoges, Loretxu; Ecochard, René; Etard, Jean-François; Carrillo-Casas, Esther; Szumilin, Elisabeth; Clinical Research Department, Epicentre, Paris, France. mar.pujades@epicentre.msf.org (2011-11)
      To compare the incidence and timing of toxicity associated with the use of a reduced dose of stavudine from 40 to 30 mg in first-line antiretroviral therapy (ART) for HIV treatment and to investigate associated risk factors.
    • Treatment Initiation, Program Attrition and Patient Treatment Outcomes associated with Scale-up and Decentralization of HIV care in rural Malawi

      McGuire, Megan; Pinoges, Loretxu; Kanapathipillai, Rupa; Munyenyembe, Tamika; Huckabee, Martha; Makombe, Simon; Szumilin, Elisabeth; Heinzelmann, Annette; Pujades-Rodríguez, Mar; Epicentre, Clinical Research Department, Nairobi, Kenya. (2012-10-15)
      To describe patient antiretroviral therapy (cART) outcomes associated with intensive decentralization of services in a rural HIV program in Malawi.