• Virologic failure and second-line antiretroviral therapy in children in South Africa--the IeDEA Southern Africa collaboration

      Davies, Mary-Ann; Moultrie, Harry; Eley, Brian; Rabie, Helena; Van Cutsem, Gilles; Giddy, Janet; Wood, Robin; Technau, Karl; Keiser, Olivia; Egger, Matthias; Boulle, Andrew; School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa; Enhancing Children's HIV Outcomes (Harriet Shezi Children's Clinic, Chris Hani Baragwanath Hospital, Soweto) and School of Public Health, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa; Red Cross Children's Hospital and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa; Tygerberg Academic Hospital, University of Stellenbosch, Stellenbosch, South Africa; Médecins Sans Frontières, Khayelitsha, South Africa and Khayelitsha ART Programme; McCord Hospital, Durban, South Africa; Gugulethu Community Health Centre and Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Empilweni Service and Research Unit, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (Lippincott Williams & Wilkins, 2011-03-01)
      With expanding pediatric antiretroviral therapy (ART) access, children will begin to experience treatment failure and require second-line therapy. We evaluated the probability and determinants of virologic failure and switching in children in South Africa.