• Selection of Plasmodium Falciparum pfcrt and pfmdr1 Polymorphisms After Treatment with Artesunate-Amodiaquine Fixed Dose Combination or Artemether-Lumefantrine in Liberia

      Otienoburu, SD; Maïga-Ascofaré, O; Schramm, B; Jullien, V; Jones, JJ; Zolia, YM; Houzé, P; Ashley, EA; Kiechel, JR; Guérin, PJ; Le Bras, J; Houzé, S (BioMed Central (Springer Science), 2016-09-05)
      Plasmodium falciparum uncomplicated malaria can successfully be treated with an artemisinin-based combination therapy (ACT). However resistance is spreading to the different ACT compounds; the artemisinin derivative and the partner drug. Studies of P. falciparum polymorphisms associated with drug resistance can provide a useful tool to track resistance and guide treatment policy as well as an in-depth understanding of the development and spread of resistance.
    • A Worldwide Map of Plasmodium Falciparum K13-Propeller Polymorphisms

      Ménard, D; Khim, N; Beghain, J; Adegnika, AA; Shafiul-Alam, M; Amodu, O; Rahim-Awab, G; Barnadas, C; Berry, A; Boum, Y; Bustos, MD; Cao, J; Chen, JH; Collet, L; Cui, L; Thakur, GD; Dieye, A; Djallé, D; Dorkenoo, MA; Eboumbou-Moukoko, CE; Espino, FEJ; Fandeur, T; Ferreira-da-Cruz, MF; Fola, AA; Fuehrer, HP; Hassan, AM; Herrera, S; Hongvanthong, B; Houzé, S; Ibrahim, ML; Jahirul-Karim, M; Jiang, L; Kano, S; Ali-Khan, W; Khanthavong, M; Kremsner, PG; Lacerda, M; Leang, R; Leelawong, M; Li, M; Lin, K; Mazarati, JB; Ménard, S; Morlais, I; Muhindo-Mavoko, H; Musset, L; Na-Bangchang, K; Nambozi, M; Niaré, K; Noedl, H; Ouédraogo, JB; Pillai, DR; Pradines, B; Quang-Phuc, B; Ramharter, M; Randrianarivelojosia, M; Sattabongkot, J; Sheikh-Omar, A; Silué, KD; Sirima, SB; Sutherland, C; Syafruddin, D; Tahar, R; Tang, LH; Touré, OA; Tshibangu-wa-Tshibangu, P; Vigan-Womas, I; Warsame, M; Wini, L; Zakeri, S; Kim, S; Eam, R; Berne, L; Khean, C; Chy, S; Ken, M; Loch, K; Canier, L; Duru, V; Legrand, E; Barale, JC; Stokes, B; Straimer, J; Witkowski, B; Fidock, DA; Rogier, C; Ringwald, P; Ariey, F; Mercereau-Puijalon, O (Massachusetts Medical Society, 2016-06-23)
      Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P. falciparum gene encoding kelch (K13)-propeller domains are the major determinant of resistance has provided opportunities for monitoring such resistance on a global scale.