• Optimal Health and Disease Management Using Spatial Uncertainty: A Geographic Characterization of Emergent Artemisinin-Resistant Plasmodium Falciparum Distributions in Southeast Asia

      Grist, EPM; Flegg, JA; Humphreys, G; Mas, IS; Anderson, TJC; Ashley, EA; Day, NPJ; Dhorda, M; Dondorp, AM; Faiz, MA; Gething, PW; Hien, TT; Hlaing, TM; Imwong, M; Kindermans, JM; Maude, RJ; Mayxay, M; McDew-White, M; Menard, D; Nair, S; Nosten, F; Newton, PN; Price, RN; Pukrittayakamee, S; Takala-Harrison, S; Smithuis, F; Nguyen, NT; Tun, KM; White, NJ; Witkowski, B; Woodrow, CJ; Fairhurst, RM; Sibley, CH; Guerin, PJ (BioMed Central, 2016-10-24)
      Artemisinin-resistant Plasmodium falciparum malaria parasites are now present across much of mainland Southeast Asia, where ongoing surveys are measuring and mapping their spatial distribution. These efforts require substantial resources. Here we propose a generic 'smart surveillance' methodology to identify optimal candidate sites for future sampling and thus map the distribution of artemisinin resistance most efficiently.