Browsing Malaria by Authors
Efficacy of Artemether-Lumefantrine in Relation to Drug Exposure in Children With and Without Severe Acute Malnutrition: an Open Comparative Intervention Study in Mali and NigerDenoeud-Ndam, L; Dicko, A; Baudin, E; Guindo, O; Grandesso, F; Diawara, H; Sissoko, S; Sanogo, K; Traoré, S; Keita, S; et al. (BioMed Central, 2016-10-24)Severe acute malnutrition (SAM) affects almost all organs and has been associated with reduced intestinal absorption of medicines. However, very limited information is available on the pharmacokinetic properties of antimalarial drugs in this vulnerable population. We assessed artemether-lumefantrine (AL) clinical efficacy in children with SAM compared to those without.