Browsing Malaria by Publisher "BioMed Central (Springer Science)"
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In Vivo Efficacy of Artesunate-Amodiaquine and Artemether-Lumefantrine for the Treatment of Uncomplicated Falciparum Malaria: an Open-Randomized, Non-Inferiority Clinical Trial in South Kivu, Democratic Republic of CongoBetween 2009 and 2012, malaria cases diagnosed in a Médecins sans Frontières programme have increased fivefold in Baraka, South Kivu, Democratic Republic of the Congo (DRC). The cause of this increase is not known. An in vivo drug efficacy trial was conducted to determine whether increased treatment failure rates may have contributed to the apparent increase in malaria diagnoses.
Selection of Plasmodium Falciparum pfcrt and pfmdr1 Polymorphisms After Treatment with Artesunate-Amodiaquine Fixed Dose Combination or Artemether-Lumefantrine in LiberiaPlasmodium falciparum uncomplicated malaria can successfully be treated with an artemisinin-based combination therapy (ACT). However resistance is spreading to the different ACT compounds; the artemisinin derivative and the partner drug. Studies of P. falciparum polymorphisms associated with drug resistance can provide a useful tool to track resistance and guide treatment policy as well as an in-depth understanding of the development and spread of resistance.