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    • Malaria
    • Browsing Malaria by Publisher
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    • 1 Published Research and Commentary
    • Malaria
    • Browsing Malaria by Publisher
    Jan 24, 2021
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    Browsing Malaria by Publisher "Oxford University Press"

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        Adapting Reactive Case Detection Strategies for falciparum Malaria in a Low-Transmission Area in Cambodia.

        Rossi, G; Van den Bergh, R; Nguon, C; Debackere, M; Vernaeve, L; Khim, N; Kim, S; Menard, D; De Smet, M; Kindermans, JM (Oxford University Press, 2018-01-06)
        Reactive case detection around falciparum malaria cases in Cambodia presents a low output. We improved it by including individuals occupationally coexposed with index case patients and using polymerase chain reaction-based diagnosis. The positivity rate increased from 0.16% to 3.9%.
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        Closing in on the Reservoir: Proactive Case Detection in High-Risk Groups as a Strategy to Detect Plasmodium falciparum Asymptomatic Carriers in Cambodia

        Rossi, Gabriele; Vernaeve, Lieven; Van den Bergh, Rafael; Nguon, Chea; Debackere, Mark; Abello Peiri, Carme; Van, Vuthea; Khim, Nimol; Kim, Saorin; Eam, Rotha; et al. (Oxford University Press, 2018-01-18)
        In the frame of elimination strategies of Plasmodium falciparum (Pf), active case detection has been recommended as complementary approach to the existing passive case detection programs. We trialed a polymerase chain reaction (PCR)-based active detection strategy targeting asymptomatic individuals, named proactive case detection (PACD), with the aim of assessing its feasibility, the extra yield of Pf infections, and the at-risk population for Pf carriage status.
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        Malaria in an Internally Displaced Persons Camp in the Democratic Republic of the Congo

        Brooks, H; Jean Paul, M; Claude, K; Houston, S; Hawkes, M (Oxford University Press, 2017-08-01)
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        Modeling of EBV Infection and Antibody Responses in Kenyan Infants with Different Levels of Malaria Exposure Shows Maternal Antibody Decay is a Major Determinant of Early EBV Infection

        Reynaldi, A; Schlub, TE; Piriou, E; Ogolla, S; Sumba, OP; Moormann, AM; Rochford, R; Davenport, MP (Oxford University Press, 2016-08-28)
        The combination of Epstein-Barr virus (EBV) infection and high malaria exposure are risk factors for endemic Burkitt lymphoma, and evidence suggests that infants in regions of high malaria exposure have earlier EBV infection and increased EBV reactivation. Here we analysed the longitudinal antibody response to EBV in Kenyan infants with different levels of malaria exposure. We found that high malaria exposure was associated with a faster decline of maternally-derived IgG antibody to both the EBV viral capsid antigen (VCA) and Epstein-Barr virus nuclear antigen (EBNA1), followed by a more rapid rise in antibody response to EBV antigens in children from the high malaria region. In addition, we observed the long-term persistence of anti-VCA IgM responses in children from the malaria high region. More rapid decay of maternal antibodies was a major predictor of EBV infection outcome, as decay predicted time-to EBV DNA detection, independent of high and low malaria exposure.
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        Performance of Rapid Diagnostic Testing in Patients with Suspected Malaria in Cambodia, a Low-Endemicity Country Aiming for Malaria Elimination

        Rossi, G; De Smet, M; Khim, N; Kindermans, JM; Menard, D (Oxford University Press, 2017-10-30)
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