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    • 1 Published Research and Commentary
    • TB
    • Browsing TB by Title
    Jan 18, 2021
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      • Thumbnail

        XDR-TB in South Africa: detention is not the priority.

        Goemaere, E; Ford, N; Berman, D; McDermid, C; Cohen, R; PLOS Medicine (2007-04)
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        Xpert(®) MTB/RIF for Detection of Mycobacterium Tuberculosis From Frozen String and Induced Sputum Sediments

        Atwebembeire, J; Orikiriza, P; Bonnet, M; Atwine, D; Katawera, V; Nansumba, M; Nyehangane, D; Bazira, J; Mwanga-Amumpaire, J; Byarugaba, F; et al. (International Union Against Tuberculosis and Lung Disease, 2016-08-01)
        Although it is now widely used for tuberculosis (TB) diagnosis, Xpert(®) MTB/RIF availability remains inadequate in low-resource settings. Moreover, its accuracy in testing stored samples from non-expectorating patients has not been evaluated.
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        Xpert® MTB/RIF under routine conditions in diagnosing pulmonary tuberculosis: a study in two hospitals in Pakistan [Short communication]

        Shah, S K; Kumar, A M V; Dogar, O F; Khan, M A; Qadeer, E; Tahseen, S; Masood, F; Chandio, A K; Edginton, M E (International Union Against TB and Lung Disease, 2013-03)
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        Yield of Systematic Longitudinal Screening of Household Contacts of Pre-Extensively Drug Resistant (PreXDR) and Extensively Drug Resistant (XDR) Tuberculosis Patients in Mumbai, India

        Paryani, RH; Gupta, V; Singh, P; Verma, M; Sheikh, S; Yadav, R; Mansoor, H; Kalon, S; Selvaraju, S; Das, M; et al. (MDPI, 2020-05-26)
        While risk of tuberculosis (TB) is high among household contacts (HHCs) of pre-extensively drug resistant (pre-XDR) TB and XDR-TB, data on yield of systematic longitudinal screening are lacking. We aim to describe the yield of systematic longitudinal TB contact tracing among HHCs of patients with pre-XDR-TB and XDR-TB. At the Médecins Sans Frontières (MSF) clinic, Mumbai, India a cohort comprising 518 HHCs of 109 pre-XDR and XDR index cases was enrolled between January 2016 and June 2018. Regular HHC follow-ups were done till one year post treatment of index cases. Of 518 HHCs, 23 had TB (21 on TB treatment and two newly diagnosed) at the time of first visit. Of the rest, 19% HHCs had no follow-ups. Fourteen (3.5%) TB cases were identified among 400 HHCs; incidence rate: 2072/100,000 person-years (95% CI: 1227-3499). The overall yield of household contact tracing was 3% (16/518). Of 14 who were diagnosed with TB during follow-up, six had drug susceptible TB (DSTB); six had pre-XDR-TB and one had XDR-TB. Five of fourteen cases had resistance patterns concordant with their index case. In view of the high incidence of TB among HHCs of pre-XDR and XDR-TB cases, follow-up of HHCs for at least the duration of index cases' treatment should be considered.
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        Zero tuberculosis at the latest International AIDS Congress in Asia and the Pacific?

        Isaakidis, P; Gupta, S; Menghaney, L (2014-04)
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