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dc.contributor.authorHovhannisyan, G*
dc.contributor.authorvon Schoen-Angerer, T*
dc.contributor.authorBabayan, K*
dc.contributor.authorFenichiu, O*
dc.contributor.authorGaboulaud, V*
dc.date.accessioned2010-12-02T19:44:17Z
dc.date.available2010-12-02T19:44:17Z
dc.date.issued2007-09-01
dc.identifier.citationSex Transm Dis 2007;34(9):686-8en
dc.identifier.issn0148-5717
dc.identifier.pmid17621247
dc.identifier.doi10.1097/01.olq.0000258433.36526.b5
dc.identifier.urihttp://hdl.handle.net/10144/116999
dc.description.abstractOBJECTIVE: There are no data available on gonococcal susceptibility in the Caucasus region. We aimed to determine in vitro antimicrobial susceptibility of Neisseria gonorrheae in Armenia in order to update the national treatment protocol. METHODS: Isolates from men with urethral discharge presenting at 3 STI clinics in 3 different sites of Armenia were used to determine susceptibility of N. gonorrheae strains for 11 antimicrobials using the disc diffusion technique. RESULTS: Among the 101 isolates tested the susceptibility rate for penicillin, doxycycline, and kanamycin were 37.6, 25.7, and 80.2%, respectively. Sensitivity to quinolones was 95% for both ofloxacin and ciprofloxacin. All strains were susceptible to third-generation cephalosporins and to spectinomycin. Only 11% of strains were susceptible to all antibiotics tested. CONCLUSION: Third-generation cephalosporines and spectinomycin are suitable first-line regimens. Quinolones are not advisable as first-line treatment given current borderline susceptibility, known tendency for rapid resistance development in this class, and frequent over-the-counter use of this antibiotic in Armenia.
dc.language.isoenen
dc.relation.urlhttp://journals.lww.com/stdjournal/pages/articleviewer.aspx?year=2007&issue=09000&article=00011&type=abstracten
dc.rightsPublished by Wolters Kluwer Lippincott Williams & Wilkins - Archived on this site by kind permission Wolters Kluweren
dc.subject.meshAnti-Bacterial Agentsen
dc.subject.meshArmeniaen
dc.subject.meshCiprofloxacinen
dc.subject.meshDoxycyclineen
dc.subject.meshGonorrheaen
dc.subject.meshHumansen
dc.subject.meshKanamycinen
dc.subject.meshMicrobial Sensitivity Testsen
dc.subject.meshNeisseria gonorrhoeaeen
dc.subject.meshOfloxacinen
dc.subject.meshPenicillinsen
dc.titleAntimicrobial susceptibility of Neisseria gonorrheae strains in three regions of Armeniaen
dc.typeArticleen
dc.contributor.departmentPrincess Margaret Hospital, Toronto, Canada; Medecins sans frontieres, Geneva, Switzerland; Medical-Scientific Center for Dermatology and STI, Yerevan, Armenia; Medecins sans frontieres, Brussels, Belgium; Epicentre, Paris, Franceen
dc.identifier.journalSexually Transmitted Diseasesen
refterms.dateFOA2019-03-04T08:32:18Z
html.description.abstractOBJECTIVE: There are no data available on gonococcal susceptibility in the Caucasus region. We aimed to determine in vitro antimicrobial susceptibility of Neisseria gonorrheae in Armenia in order to update the national treatment protocol. METHODS: Isolates from men with urethral discharge presenting at 3 STI clinics in 3 different sites of Armenia were used to determine susceptibility of N. gonorrheae strains for 11 antimicrobials using the disc diffusion technique. RESULTS: Among the 101 isolates tested the susceptibility rate for penicillin, doxycycline, and kanamycin were 37.6, 25.7, and 80.2%, respectively. Sensitivity to quinolones was 95% for both ofloxacin and ciprofloxacin. All strains were susceptible to third-generation cephalosporins and to spectinomycin. Only 11% of strains were susceptible to all antibiotics tested. CONCLUSION: Third-generation cephalosporines and spectinomycin are suitable first-line regimens. Quinolones are not advisable as first-line treatment given current borderline susceptibility, known tendency for rapid resistance development in this class, and frequent over-the-counter use of this antibiotic in Armenia.


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