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    Mar 04, 2021
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    Loss of correlation between HIV viral load and CD4+ T-cell counts in HIV/HTLV-1 co-infection in treatment naive Mozambican patients

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    Authors
    Bhatt, N B
    Gudo, E S
    Semá, C
    Bila, D
    Di Mattei, P
    Augusto, O
    Garsia, R
    Jani, I V
    Affiliation
    Department of Immunology, Instituto Nacional de Saúde, Maputo, Mozambique; HIV Outpatient Clinic, Alto Mae Health Centre, Medecins Sans Frontieres, Switzerland, Maputo, Mozambique; Department of Medicine, University of Sydney, New South Wales, Australia;Department of Clinical Immunology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Issue Date
    2009-12-01
    Submitted date
    2010-10-15
    
    Metadata
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    Journal
    International Journal of STD & AIDS
    Abstract
    Seven hundred and four HIV-1/2-positive, antiretroviral therapy (ART) naïve patients were screened for HTLV-1 infection. Antibodies to HTLV-1 were found in 32/704 (4.5%) of the patients. Each co-infected individual was matched with two HIV mono-infected patients according to World Health Organization clinical stage, age +/-5 years and gender. Key clinical and laboratory characteristics were compared between the two groups. Mono-infected and co-infected patients displayed similar clinical characteristics. However, co-infected patients had higher absolute CD4+ T-cell counts (P = 0.001), higher percentage CD4+ T-cell counts (P < 0.001) and higher CD4/CD8 ratios (P < 0.001). Although HIV plasma RNA viral loads were inversely correlated with CD4+ T-cell-counts in mono-infected patients (P < 0.0001), a correlation was not found in co-infected individuals (P = 0.11). Patients with untreated HIV and HTLV-1 co-infection show a dissociation between immunological and HIV virological markers. Current recommendations for initiating ART and chemoprophylaxis against opportunistic infections in resource-poor settings rely on more readily available CD4+ T-cell counts without viral load parameters. These guidelines are not appropriate for co-infected individuals in whom high CD4+ T-cell counts persist despite high HIV viral load states. Thus, for co-infected patients, even in resource-poor settings, HIV viral loads are likely to contribute information crucial for the appropriate timing of ART introduction.
    URI
    http://hdl.handle.net/10144/117166
    DOI
    10.1258/ijsa.2008.008401
    PubMed ID
    19948902
    Additional Links
    http://ijsa.rsmjournals.com/cgi/content/full/20/12/863
    Type
    Article
    Language
    en
    ISSN
    0956-4624
    ae974a485f413a2113503eed53cd6c53
    10.1258/ijsa.2008.008401
    Scopus Count
    Collections
    HIV/AIDS

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