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dc.contributor.authorCox, H
dc.contributor.authorvan Cutsem, G
dc.date.accessioned2011-03-09T20:06:37Z
dc.date.available2011-03-09T20:06:37Z
dc.date.issued2010-12-09
dc.date.submitted2011-03-08
dc.identifier.citationLancet 2010;377(9760):103-4en
dc.identifier.issn1474-547X
dc.identifier.pmid21145582
dc.identifier.doi10.1016/S0140-6736(10)61390-6
dc.identifier.urihttp://hdl.handle.net/10144/124085
dc.description.abstractOf the estimated half a million people who develop multidrug resistant (MDR) tuberculosis each year, less than 7% are diagnosed and only 1 in 5 of these have access to eff ective treatment.1 To control this epidemic, dramatically increased efforts are required to scale up case detection and treatment provision. In The Lancet, Mercedes Becerra and colleagues2 report the yield of additional MDR tuberculosis diagnoses that are found by screening household contacts of index cases in Lima, Peru. This study—the largest of its kind to date—found that more than 2% of 4503 household contacts had active tuberculosis at the time the index case was diagnosed. Incident tuberculosis was also found at a rate of 1624 cases per 100 000 person-years over 4 years follow-up. These results support recommendations for active screening of household contacts of people with MDR tuberculosis,3 and provide valuable lessons for other programmes striving to improve case detection and to reduce community transmission of MDR tuberculosis.
dc.language.isoenen
dc.relation.urlhttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2961390-6/fulltexten
dc.rightsReproduced on this site with permission of Elsevier Ltd. Please see [url]http://www.thelancet.com/[/url] for further relevant comment.en
dc.subject.meshAmbulatory Careen
dc.subject.meshAntitubercular Agentsen
dc.subject.meshContact Tracingen
dc.subject.meshCost of Illnessen
dc.subject.meshCoughen
dc.subject.meshFamily Characteristicsen
dc.subject.meshHealth Educationen
dc.subject.meshHumansen
dc.subject.meshHygieneen
dc.subject.meshInfection Controlen
dc.subject.meshPatient Education as Topicen
dc.subject.meshPeruen
dc.subject.meshPopulation Surveillanceen
dc.subject.meshPrevalenceen
dc.subject.meshSputumen
dc.subject.meshTuberculosis, Multidrug-Resistanten
dc.subject.meshTuberculosis, Pulmonaryen
dc.titleHousehold screening and multidrug-resistant tuberculosisen
dc.typeArticleen
dc.contributor.departmentBurnet Institute for Medical Research and Public Health, Centre for Population Health, Melbourne, Australia; Médecins Sans Frontières, Cape Town, South Africaen
dc.identifier.journalLanceten
refterms.dateFOA2019-03-04T08:38:48Z
html.description.abstractOf the estimated half a million people who develop multidrug resistant (MDR) tuberculosis each year, less than 7% are diagnosed and only 1 in 5 of these have access to eff ective treatment.1 To control this epidemic, dramatically increased efforts are required to scale up case detection and treatment provision. In The Lancet, Mercedes Becerra and colleagues2 report the yield of additional MDR tuberculosis diagnoses that are found by screening household contacts of index cases in Lima, Peru. This study—the largest of its kind to date—found that more than 2% of 4503 household contacts had active tuberculosis at the time the index case was diagnosed. Incident tuberculosis was also found at a rate of 1624 cases per 100 000 person-years over 4 years follow-up. These results support recommendations for active screening of household contacts of people with MDR tuberculosis,3 and provide valuable lessons for other programmes striving to improve case detection and to reduce community transmission of MDR tuberculosis.


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