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    Jan 16, 2021
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    Developments in the treatment of visceral leishmaniasis

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    090901_denBoer_VL-drug-devel_E ...
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    Authors
    den Boer, Margriet Leontine
    Alvar, Jorge
    Davidson, Robert N
    Ritmeijer, Koert
    Balasegaram, Manica
    Affiliation
    Medecins Sans Frontieres, Amsterdam, The Netherlands
    Issue Date
    2009-09-01
    Submitted date
    2010-10-15
    
    Metadata
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    Journal
    Expert Opinion on Emerging Drugs
    Abstract
    BACKGROUND: Visceral leishmaniasis (VL) is one of the most neglected parasitic diseases causing large scale mortality and morbidity among the poorest of the poor in the Indian subcontinent and Africa. OBJECTIVE: This review aims to describe the potential and the (lack of) current impact of newly developed treatments on the control of VL. It describes how the problem of an empty research pipeline is addressed, and discusses the emerging threat of incurable HIV/VL coinfection. METHODS: The literature was searched for drugs used in VL. CONCLUSION: Research and development of VL drugs has received a financial boost but no new drugs are expected in the next 5 years. Only three new and highly effective treatments have been licensed in the past 10 years. These remain, however, largely inaccessible as VL control programs in the developing world are lacking. This is deserving of immediate and urgent attention, especially in the context of the rapidly expanding HIV/VL coinfection.
    URI
    http://hdl.handle.net/10144/127729
    DOI
    10.1517/14728210903153862
    PubMed ID
    19708817
    Additional Links
    http://informahealthcare.com/doi/abs/10.1517/14728210903153862
    Type
    Article
    Language
    en
    ISSN
    1744-7623
    ae974a485f413a2113503eed53cd6c53
    10.1517/14728210903153862
    Scopus Count
    Collections
    Leishmaniasis/Kala Azar

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