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    Jan 16, 2021
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    Challenges in measuring measles case fatality ratios in settings without vital registration.

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    Authors
    Cairns, K Lisa
    Nandy, Robin
    Grais, Rebecca F
    Affiliation
    Global Immunization Division, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS E-05, Atlanta, GA 30333, USA. kfc4@cdc.gov.
    Issue Date
    2010
    
    Metadata
    Show full item record
    Journal
    Emerging Themes in Epidemiology
    Abstract
    ABSTRACT: Measles, a highly infectious vaccine-preventable viral disease, is potentially fatal. Historically, measles case-fatality ratios (CFRs) have been reported to vary from 0.1% in the developed world to as high as 30% in emergency settings. Estimates of the global burden of mortality from measles, critical to prioritizing measles vaccination among other health interventions, are highly sensitive to the CFR estimates used in modeling; however, due to the lack of reliable, up-to-date data, considerable debate exists as to what CFR estimates are appropriate to use. To determine current measles CFRs in high-burden settings without vital registration we have conducted six retrospective measles mortality studies in such settings. This paper examines the methodological challenges of this work and our solutions to these challenges, including the integration of lessons from retrospective all-cause mortality studies into CFR studies, approaches to laboratory confirmation of outbreaks, and means of obtaining a representative sample of case-patients. Our experiences are relevant to those conducting retrospective CFR studies for measles or other diseases, and to those interested in all-cause mortality studies.
    URI
    http://hdl.handle.net/10144/128609
    DOI
    10.1186/1742-7622-7-4
    PubMed ID
    20642812
    Additional Links
    http://www.ete-online.com
    Type
    Article
    Language
    en
    ISSN
    1742-7622
    ae974a485f413a2113503eed53cd6c53
    10.1186/1742-7622-7-4
    Scopus Count
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    Other Diseases

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