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dc.contributor.authorCairns, K Lisa
dc.contributor.authorNandy, Robin
dc.contributor.authorGrais, RFebecca F
dc.date.accessioned2011-04-21T20:46:36Z
dc.date.available2011-04-21T20:46:36Z
dc.date.issued2010
dc.identifier.citationChallenges in measuring measles case fatality ratios in settings without vital registration. 2010, 7 (1):4 Emerg Themes Epidemiolen
dc.identifier.issn1742-7622
dc.identifier.pmid20642812
dc.identifier.doi10.1186/1742-7622-7-4
dc.identifier.urihttp://hdl.handle.net/10144/128609
dc.description.abstractABSTRACT: Measles, a highly infectious vaccine-preventable viral disease, is potentially fatal. Historically, measles case-fatality ratios (CFRs) have been reported to vary from 0.1% in the developed world to as high as 30% in emergency settings. Estimates of the global burden of mortality from measles, critical to prioritizing measles vaccination among other health interventions, are highly sensitive to the CFR estimates used in modeling; however, due to the lack of reliable, up-to-date data, considerable debate exists as to what CFR estimates are appropriate to use. To determine current measles CFRs in high-burden settings without vital registration we have conducted six retrospective measles mortality studies in such settings. This paper examines the methodological challenges of this work and our solutions to these challenges, including the integration of lessons from retrospective all-cause mortality studies into CFR studies, approaches to laboratory confirmation of outbreaks, and means of obtaining a representative sample of case-patients. Our experiences are relevant to those conducting retrospective CFR studies for measles or other diseases, and to those interested in all-cause mortality studies.
dc.language.isoenen
dc.relation.urlhttp://www.ete-online.comen
dc.rightsArchived with thanks to Emerging Themes in Epidemiology and Open Access permission.en
dc.titleChallenges in measuring measles case fatality ratios in settings without vital registration.en
dc.typeArticleen
dc.contributor.departmentGlobal Immunization Division, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS E-05, Atlanta, GA 30333, USA. kfc4@cdc.gov.en
dc.identifier.journalEmerging Themes in Epidemiologyen
refterms.dateFOA2019-03-04T08:44:40Z
html.description.abstractABSTRACT: Measles, a highly infectious vaccine-preventable viral disease, is potentially fatal. Historically, measles case-fatality ratios (CFRs) have been reported to vary from 0.1% in the developed world to as high as 30% in emergency settings. Estimates of the global burden of mortality from measles, critical to prioritizing measles vaccination among other health interventions, are highly sensitive to the CFR estimates used in modeling; however, due to the lack of reliable, up-to-date data, considerable debate exists as to what CFR estimates are appropriate to use. To determine current measles CFRs in high-burden settings without vital registration we have conducted six retrospective measles mortality studies in such settings. This paper examines the methodological challenges of this work and our solutions to these challenges, including the integration of lessons from retrospective all-cause mortality studies into CFR studies, approaches to laboratory confirmation of outbreaks, and means of obtaining a representative sample of case-patients. Our experiences are relevant to those conducting retrospective CFR studies for measles or other diseases, and to those interested in all-cause mortality studies.


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