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    Jan 26, 2021
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    Modelling the first dose of measles vaccination: the role of maternal immunity, demographic factors, and delivery systems.

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    Authors
    Metcalf, C J E
    Klepac, P
    Ferrari, M
    Grais, R F
    Djibo, A
    Grenfell, B T
    Affiliation
    Department of Ecology and Evolutionary Biology, Princeton University, NJ 0854, USA. cmetcalf@princeton.edu
    Issue Date
    2011-02
    
    Metadata
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    Journal
    Epidemiology and Infection
    Abstract
    Measles vaccine efficacy is higher at 12 months than 9 months because of maternal immunity, but delaying vaccination exposes the children most vulnerable to measles mortality to infection. We explored how this trade-off changes as a function of regionally varying epidemiological drivers, e.g. demography, transmission seasonality, and vaccination coverage. High birth rates and low coverage both favour early vaccination, and initiating vaccination at 9-11 months, then switching to 12-14 months can reduce case numbers. Overall however, increasing the age-window of vaccination decreases case numbers relative to vaccinating within a narrow age-window (e.g. 9-11 months). The width of the age-window that minimizes mortality varies as a function of birth rate, vaccination coverage and patterns of access to care. Our results suggest that locally age-targeted strategies, at both national and sub-national scales, tuned to local variation in birth rate, seasonality, and access to care may substantially decrease case numbers and fatalities for routine vaccination.
    Publisher
    Cambridge University Press
    URI
    http://hdl.handle.net/10144/129954
    DOI
    10.1017/S0950268810001329
    PubMed ID
    20525415
    Additional Links
    http://journalseek.net/
    Type
    Article
    Language
    en
    ISSN
    1469-4409
    ae974a485f413a2113503eed53cd6c53
    10.1017/S0950268810001329
    Scopus Count
    Collections
    Other Diseases

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