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dc.contributor.authorBertherat, Eric
dc.contributor.authorThullier, Philippe
dc.contributor.authorShako, Jean Christophe
dc.contributor.authorEngland, Kathleen
dc.contributor.authorKone, Mamadou Lamine
dc.contributor.authorArntzen, Lorraine
dc.contributor.authorTomaso, Herbert
dc.contributor.authorKoyange, Louis
dc.contributor.authorFormenty, Pierre
dc.contributor.authorEkwanzala, Florent
dc.contributor.authorCrestani, Rosa
dc.contributor.authorCiglenecki, Isa
dc.contributor.authorCiglenecki, Isa
dc.contributor.authorRahalison, Lila
dc.date.accessioned2011-08-31T18:56:35Z
dc.date.available2011-08-31T18:56:35Z
dc.date.issued2011-04-25
dc.date.submitted2011-05-26
dc.identifier.citationEmerg Infect Dis; 2011;17 (5):778-784en
dc.identifier.issn1080-6059
dc.identifier.pmid21529384
dc.identifier.urihttp://hdl.handle.net/10144/141432
dc.description.abstractPneumonic plague is a highly transmissible infectious disease for which fatality rates can be high if untreated; it is considered extremely lethal. Without prompt diagnosis and treatment, disease management can be problematic. In the Democratic Republic of the Congo, 2 outbreaks of pneumonic plague occurred during 2005 and 2006. In 2005, because of limitations in laboratory capabilities, etiology was confirmed only through retrospective serologic studies. This prompted modifications in diagnostic strategies, resulting in isolation of Yersinia pestis during the second outbreak. Results from these outbreaks demonstrate the utility of a rapid diagnostic test detecting F1 antigen for initial diagnosis and public health management, as well as the need for specialized sampling kits and trained personnel for quality specimen collection and appropriate specimen handling and preservation for plague confirmation and Y. pestis isolation. Efficient frontline management and a streamlined diagnostic strategy are essential for confirming plague, especially in remote areas.
dc.languageENG
dc.language.isoenen
dc.relation.urlhttp://www.cdc.gov/EID/content/17/5/778_cme_followup.htmen
dc.rightsPublished by Centers for Disease Control (CDC) Archived on this site by permission of CDC, [url]http://www.cdc.gov/ncidod/eid[/url]en
dc.subject.meshPneumonic Plagueen
dc.titleLessons Learned about Pneumonic Plague Diagnosis from 2 Outbreaks, Democratic Republic of the Congoen
dc.typeArticleen
dc.contributor.departmentWorld Health Organization, Geneva, Switzerland; Centre de Recherche du Service de Sante des Armees, Grenoble, France; Plague Reference Laboratory, Bunia, Democratic Republic of the Congo; National Institutes of Health, Bethesda, Maryland, USA; World Health Organization, Brazzaville, Republic of Congo; National Health Laboratory Service, Johannesburg, South Africa; Bundeswehr Institute of Microbiology, Munich, Germany; Institut National de la Recherche Biomedicale, Kinshasa, Democratic Republic of the Congo; World Health Organization, Kinshasa; Medecins Sans Frontiere, Bruxelles, Belgium; Medecins sans Frontieres, Geneva; Institut Pasteur, Antananarivo, Madagascaren
dc.identifier.journalEmerging Infectious Diseasesen
refterms.dateFOA2019-03-04T08:48:08Z
html.description.abstractPneumonic plague is a highly transmissible infectious disease for which fatality rates can be high if untreated; it is considered extremely lethal. Without prompt diagnosis and treatment, disease management can be problematic. In the Democratic Republic of the Congo, 2 outbreaks of pneumonic plague occurred during 2005 and 2006. In 2005, because of limitations in laboratory capabilities, etiology was confirmed only through retrospective serologic studies. This prompted modifications in diagnostic strategies, resulting in isolation of Yersinia pestis during the second outbreak. Results from these outbreaks demonstrate the utility of a rapid diagnostic test detecting F1 antigen for initial diagnosis and public health management, as well as the need for specialized sampling kits and trained personnel for quality specimen collection and appropriate specimen handling and preservation for plague confirmation and Y. pestis isolation. Efficient frontline management and a streamlined diagnostic strategy are essential for confirming plague, especially in remote areas.


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