• Login
    View Item 
    •   Home
    • 1 Published Research and Commentary
    • Trypanosomiasis/Sleeping Sickness
    • View Item
    •   Home
    • 1 Published Research and Commentary
    • Trypanosomiasis/Sleeping Sickness
    • View Item
    Mar 02, 2021
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MSFTitleAuthorsSubjectsPublisherJournalThis CollectionTitleAuthorsSubjectsPublisherJournal

    Card Agglutination Test for Trypanosomiasis (CATT) End-Dilution Titer and Cerebrospinal Fluid Cell Count as Predictors of Human African Trypanosomiasis (Trypanosoma brucei gambiense) Among Serologically Suspected Individuals in Southern Sudan.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    chappuis.pdf
    Size:
    71.62Kb
    Format:
    PDF
    Download
    Authors
    Chappuis, F
    Stivanello, E
    Adams, K
    Kidane, S
    Pittet, A
    Bovier, P A
    Affiliation
    Médecins Sans Frontières, Swiss Section, Geneva, Switzerland. francois.chappuis@hcuge.ch
    Issue Date
    2004-09
    
    Metadata
    Show full item record
    Journal
    American Journal of Tropical Medicine and Hygiene
    Abstract
    The diagnosis of human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense relies on an initial serologic screening with the card agglutination test for trypanosomiasis (CATT) for T. b. gambiense, followed by parasitologic confirmation in most endemic areas. Unfortunately, field parasitologic methods lack sensitivity and the management of serologically suspected individuals (i.e., individuals with a positive CATT result but negative parasitology) remains controversial. In Kajo-Keji County in southern Sudan, we prospectively collected sociodemographic and laboratory data of a cohort of 2,274 serologically suspected individuals. Thirty-three percent (n = 749) attended at least one follow-up visit and HAT was confirmed in 64 (9%) cases. Individuals with lower initial CATT-plasma (CATT-P) end-dilution titers had lowest risks (10.4 and 13.8/100 person-years for 1:4 and 1:8 titers, respectively) that significantly increased for higher dilutions: relative risks = 5.1 (95% confidence interval [CI] = 2.6-9.5) and 4.6 (95% CI = 2.8-9.8) for 1:16 and 1:32 titers, respectively. The cumulative yearly risk was also high (76%) in individuals found with 11-20 cells in the cerebrospinal fluid, but this involved only eight patients. Adjustment for potential confounders did not affect the results. In conclusion, treatment with pentamidine should be considered for all serologically suspected individuals with a CATT-P end-dilution titer >/= 1:16 in areas of a moderate to high prevalence of HAT.
    Publisher
    Published by: American Society of Tropical Medicine and Hygiene
    URI
    http://hdl.handle.net/10144/17233
    PubMed ID
    15381812
    Additional Links
    http://www.ajtmh.org
    Language
    en
    ISSN
    0002-9637
    Collections
    Trypanosomiasis/Sleeping Sickness

    entitlement

    Related articles

    • Evaluation of the micro-CATT, CATT/Trypanosoma brucei gambiense, and LATEX/T b gambiense methods for serodiagnosis and surveillance of human African trypanosomiasis in West and Central Africa.
    • Authors: Truc P, Lejon V, Magnus E, Jamonneau V, Nangouma A, Verloo D, Penchenier L, Büscher P
    • Issue date: 2002
    • Field evaluation of the CATT/Trypanosoma brucei gambiense on blood-impregnated filter papers for diagnosis of human African trypanosomiasis in southern Sudan.
    • Authors: Chappuis F, Pittet A, Bovier PA, Adams K, Godineau V, Hwang SY, Magnus E, Büscher P
    • Issue date: 2002 Nov
    • An evaluation of the reactivity of the card agglutination test for trypanosomiasis (CATT) reagent in the Fontem sleeping sickness focus, Cameroon.
    • Authors: Asonganyi T, Bedifeh BA, Ade SS, Ngu JL
    • Issue date: 1994 Mar
    • A CATT negative result after treatment for human African trypanosomiasis is no indication for cure.
    • Authors: Lejon V, Ngoyi DM, Boelaert M, Büscher P
    • Issue date: 2010 Jan 26
    • [The efficiency of different detection strategies of human African trypanosomiasis by T. b. gambiense].
    • Authors: Lutumba P, Robays J, Miaka C, Kande V, Simarro PP, Shaw AP, Dujardin B, Boelaert M
    • Issue date: 2005 Apr
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.