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dc.contributor.authorWeill, F X
dc.contributor.authorTran, H H
dc.contributor.authorRoumagnac, P
dc.contributor.authorFabre, L
dc.contributor.authorMinh, N B
dc.contributor.authorStavnes, T L
dc.contributor.authorLassen, J
dc.contributor.authorBjune, G
dc.contributor.authorGrimont, P A D
dc.contributor.authorGuerin, P J
dc.date.accessioned2008-01-31T15:30:43Z
dc.date.available2008-01-31T15:30:43Z
dc.date.issued2007-06
dc.identifier.citationClonal reconquest of antibiotic-susceptible Salmonella enterica serotype Typhi in Son La Province, Vietnam. 2007, 76 (6):1174-81 Am. J. Trop. Med. Hyg.en
dc.identifier.issn0002-9637
dc.identifier.pmid17556632
dc.identifier.urihttp://hdl.handle.net/10144/17240
dc.description.abstractIn the last three decades, high rates of resistance to common first-line antimicrobial agents have been reported in Salmonella enterica serotype Typhi (Typhi), the causative organism of typhoid fever (TF), in many regions of the world, especially in South East Asia. Analysis of Typhi strains isolated from outbreaks and sporadic cases of TF in Son La province, northwest Vietnam, in 2002 revealed that 94.5% (85/90) of the isolates were fully susceptible to amoxicillin, chloramphenicol, cotrimoxazole, tetracycline, and nalidixic acid. There was a clear decline in the occurrence of multi-drug resistant (MDR) Typhi isolates collected in this province in 2002 (4.4%) compared with the period 1995-1999 in the same province (30.8-100%). By using molecular (IS200 profiling, PstI-ribotyping, XbaI-pulsed-field gel electrophoresis, and haplotyping) and phage-typing methods, we showed that the Typhi isolates from Son La province in 2002 were genetically related; however, they were unrelated to the previous MDR clones established in Vietnam.
dc.language.isoenen
dc.rightsArchived on this site with the kind permission of the American Society of Tropical Medicine and Hygiene, www.astmh.orgen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAnti-Bacterial Agentsen
dc.subject.meshBacteriophage Typingen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshDNA Transposable Elementsen
dc.subject.meshDNA, Bacterialen
dc.subject.meshDisease Outbreaksen
dc.subject.meshElectrophoresis, Gel, Pulsed-Fielden
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPovertyen
dc.subject.meshRibotypingen
dc.subject.meshSalmonella typhien
dc.subject.meshTyphoid Feveren
dc.subject.meshVietnamen
dc.titleClonal reconquest of antibiotic-susceptible Salmonella enterica serotype Typhi in Son La Province, Vietnam.en
dc.contributor.departmentCentre National de Référence des Salmonella, Centre Collaborateur OMS de Référence et de Recherche pour les Salmonella, Unité de Biodiversité des Bactéries Pathogènes Emergentes, INSERM U389, Institut Pasteur, Paris, France. fxweill@pasteur.fren
dc.identifier.journalAmerican Journal of Tropical Medicine and Hygieneen
refterms.dateFOA2019-03-04T08:56:41Z
html.description.abstractIn the last three decades, high rates of resistance to common first-line antimicrobial agents have been reported in Salmonella enterica serotype Typhi (Typhi), the causative organism of typhoid fever (TF), in many regions of the world, especially in South East Asia. Analysis of Typhi strains isolated from outbreaks and sporadic cases of TF in Son La province, northwest Vietnam, in 2002 revealed that 94.5% (85/90) of the isolates were fully susceptible to amoxicillin, chloramphenicol, cotrimoxazole, tetracycline, and nalidixic acid. There was a clear decline in the occurrence of multi-drug resistant (MDR) Typhi isolates collected in this province in 2002 (4.4%) compared with the period 1995-1999 in the same province (30.8-100%). By using molecular (IS200 profiling, PstI-ribotyping, XbaI-pulsed-field gel electrophoresis, and haplotyping) and phage-typing methods, we showed that the Typhi isolates from Son La province in 2002 were genetically related; however, they were unrelated to the previous MDR clones established in Vietnam.


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