Case management of a multidrug-resistant Shigella dysenteriae serotype 1 outbreak in a crisis context in Sierra Leone, 1999-2000.
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AbstractFrom December 1999 to the end of February 2000, 4218 cases of dysentery were reported in Kenema district, southeastern Sierra Leone, by a Médecins Sans Frontières team operating in this region. Shigella dysenteriae serotype 1 was isolated from the early cases. The overall attack rate was 7.5% but higher among children under 5 years (11.2%) compared to the rest of the population (6.8%) (RR = 1.6; 95% CI 1.5-1.8). The case fatality ratio was 3.1%, and higher for children under 5 years (6.1% vs. 2.1%) (RR = 2.9; 95% CI 2.1-4.1). A case management strategy based on stratification of affected cases was chosen in this resource-poor setting. Patients considered at higher risk of death were treated with a 5 day ciprofloxacin regimen in isolation centres. Five hundred and eighty-three cases were treated with a case fatality ratio of 0.9%. Patients who did not have signs of severity when seen by health workers were given hygiene advice and oral rehydration salts. This strategy was effective in this complex emergency.
- Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone.
- Authors: Guerin PJ, Brasher C, Baron E, Mic D, Grimont F, Ryan M, Aavitsland P, Legros D
- Issue date: 2003 Aug 30
- Multidrug resistant epidemic shigellosis in a village in west Bengal, 1984.
- Authors: Sengupta PG, Mandal S, Sen D, Das P, Deb BC, Pal SC
- Issue date: 1990 Jan-Mar
- [Ciprofloxacin in the treatment of dysentery caused by type 1 Shigella dysenteriae during an epidemic in Rwandan refugees in Goma in 1994].
- Authors: Laureillard D, Paquet C, Malvy D
- Issue date: 1998 Jul-Aug
- [An outbreak of Shigella dysenteriae type 1 dysentery in a refugee camp in Rwanda].
- Authors: Paquet C, Leborgne P, Sasse A, Varaine F
- Issue date: 1995 May-Jun
- Antimicrobial susceptibility of Shigella flexneri and S. dysenteriae isolated from stool specimens of patients with bloody diarrhoea in Mwanza, Tanzania.
- Authors: Temu MM, Kaatano GM, Miyaye ND, Buhalata SN, Shushu ML, Kishamawe C, Changalucha JM
- Issue date: 2007 Sep