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dc.contributor.authorZachariah, R*
dc.contributor.authorHarries, A D*
dc.contributor.authorArendt, V*
dc.contributor.authorWennig, R*
dc.contributor.authorSchneider, S*
dc.contributor.authorSpielmann M P*
dc.contributor.authorPanarotto, E*
dc.contributor.authorGomani, P*
dc.contributor.authorSalaniponi, F M L*
dc.date.accessioned2008-01-31T16:00:36Z
dc.date.available2008-01-31T16:00:36Z
dc.date.issued2001-09
dc.identifier.citationCompliance with Cotrimoxazole Prophylaxis for the Prevention of Opportunistic Infections in HIV-Positive Tuberculosis Patients in Thyolo District, Malawi. 2001, 5 (9):843-6 Int. J. Tuberc. Lung Dis.en
dc.identifier.issn1027-3719
dc.identifier.pmid11573896
dc.identifier.urihttp://hdl.handle.net/10144/17264
dc.description.abstractOBJECTIVE: To verify compliance with cotrimoxazole prophylaxis in human immunodeficiency virus (HIV) infected tuberculosis (TB) patients during the continuation phase of anti-tuberculosis treatment, and to assess the sensitivity, specificity and positive predictive values of verbal verification and pill counts as methods of checking compliance. DESIGN: Cross-sectional study. METHODS: Cotrimoxazole compliance was assessed in a cohort of TB patients who were attending four TB follow-up centres during the continuation phase of anti-TB treatment between months 4 and 6. Verbal verification of drug intake, physical verification of pill count balance, and urine trimethoprim detection by gas chromatography and mass spectrometry were used for assessing compliance. RESULTS: Using urine trimethoprim detection as the gold standard for compliance, trimethoprim was detected in 82 (94%) of 87 patients in the cohort. Verbal verification of cotrimoxazole intake and objective pill count balances showed high sensitivity and positive predictive values compared with the gold standard of urine trimethoprim detection. CONCLUSIONS: In a rural district in Malawi, compliance with cotrimoxazole as an adjunct to anti-tuberculosis treatment in HIV-infected TB patients was good, and can be assessed simply and practically by verbal verification and pill counts.
dc.language.isoenen
dc.publisherInternational Union Against TB and Lung Disease
dc.relation.urlhttp://www.ingentaconnect.com/content/iuatld/ijtld
dc.rightsArchived on this site with the kind permission of the International Union Against TB and Lung Disease, http://www.iuatld.orgen
dc.subject.meshAIDS-Related Opportunistic Infectionsen
dc.subject.meshAdulten
dc.subject.meshAnti-Infective Agentsen
dc.subject.meshAntitubercular Agentsen
dc.subject.meshCohort Studiesen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshFemaleen
dc.subject.meshGas Chromatography-Mass Spectrometryen
dc.subject.meshHumansen
dc.subject.meshMalawien
dc.subject.meshMaleen
dc.subject.meshPatient Complianceen
dc.subject.meshPredictive Value of Testsen
dc.subject.meshRural Populationen
dc.subject.meshSelf Administrationen
dc.subject.meshSensitivity and Specificityen
dc.subject.meshTrimethoprim-Sulfamethoxazole Combinationen
dc.subject.meshTuberculosisen
dc.titleCompliance with Cotrimoxazole Prophylaxis for the Prevention of Opportunistic Infections in HIV-Positive Tuberculosis Patients in Thyolo District, Malawi.en
dc.contributor.departmentMedecins sans Frontieres-Luxembourg, Thyolo District, Malawi. msflblantyre@malawi.neten
dc.identifier.journalInternational Journal of Tuberculosis and Lung Diseaseen
refterms.dateFOA2019-03-04T09:02:00Z
html.description.abstractOBJECTIVE: To verify compliance with cotrimoxazole prophylaxis in human immunodeficiency virus (HIV) infected tuberculosis (TB) patients during the continuation phase of anti-tuberculosis treatment, and to assess the sensitivity, specificity and positive predictive values of verbal verification and pill counts as methods of checking compliance. DESIGN: Cross-sectional study. METHODS: Cotrimoxazole compliance was assessed in a cohort of TB patients who were attending four TB follow-up centres during the continuation phase of anti-TB treatment between months 4 and 6. Verbal verification of drug intake, physical verification of pill count balance, and urine trimethoprim detection by gas chromatography and mass spectrometry were used for assessing compliance. RESULTS: Using urine trimethoprim detection as the gold standard for compliance, trimethoprim was detected in 82 (94%) of 87 patients in the cohort. Verbal verification of cotrimoxazole intake and objective pill count balances showed high sensitivity and positive predictive values compared with the gold standard of urine trimethoprim detection. CONCLUSIONS: In a rural district in Malawi, compliance with cotrimoxazole as an adjunct to anti-tuberculosis treatment in HIV-infected TB patients was good, and can be assessed simply and practically by verbal verification and pill counts.


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