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    Apr 11, 2021
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    Evaluation of Three Rapid Tests for Diagnosis of P. Falciparum and P. Vivax Malaria in Colombia.

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    Authors
    van den Broek, I
    Hill, O
    Gordillo, F
    Angarita, B
    Hamade, P
    Counihan, H
    Guthmann, J P
    Affiliation
    Médecins sans Frontières (MSF), London, UK. ingrid_vandenbroek@yahoo.com
    Issue Date
    2006-12
    
    Metadata
    Show full item record
    Journal
    The American Journal of Tropical Medicine and Hygiene
    Abstract
    The diagnostic capacity of three malaria rapid diagnostic tests (RDTs), NOW-Malaria-ICT, OptiMAL-IT, and Paracheck-Pf, was evaluated against expert microscopy in Colombia. We tested 896 patients, of whom microscopy confirmed 139 P. falciparum, 279 P. vivax, and 13 mixed P.f/P.v infections and 465 negatives. Paracheck-Pf and NOW-malaria-ICT were more accurate in detecting P. falciparum (sensitivities 90.8% and 90.1%, respectively) in comparison with Optimal-IT (83.6%). NOW showed an acceptable Pf detection rate at low densities (< 500/microL), but resulted in a higher proportion of false positives. For P. vivax diagnosis, Optimal-IT had a higher sensitivity than NOW (91.0% and 81.4%, respectively). The choice between the two Pf/Pv detecting RDTs balances P. falciparum and P. vivax detection rates. Considering some degree of P. falciparum overtreatment and failure to detect all P. vivax cases as more acceptable than missing some cases of P. falciparum, we recommend careful implementation of NOW-malaria-ICT in areas where microscopy is lacking. The price is however still a constraint.
    URI
    http://hdl.handle.net/10144/17270
    PubMed ID
    17172395
    Language
    en
    ISSN
    0002-9637
    Collections
    Malaria

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