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dc.contributor.authorGuthmann, J P*
dc.contributor.authorKasparian, S*
dc.contributor.authorPhetsouvanh, R*
dc.contributor.authorNathan, N*
dc.contributor.authorGarcia, M*
dc.contributor.authorPhompida, S*
dc.contributor.authorBrockman, A*
dc.contributor.authorGastellu-Etchegorry, M*
dc.contributor.authorLegros, D*
dc.date.accessioned2008-01-31T16:07:31Z
dc.date.available2008-01-31T16:07:31Z
dc.date.issued2002-09
dc.identifier.citationThe Efficacy of Chloroquine for the Treatment of Acute, Uncomplicated, Plasmodium Falciparum Malaria in Laos. 2002, 96 (6):553-7 Ann. Trop. Med. Parasitol.
dc.identifier.issn0003-4983
dc.identifier.pmid12396318
dc.identifier.doi10.1179/000349802125001654
dc.identifier.urihttp://hdl.handle.net/10144/17278
dc.description.abstractTo assess the local efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria, children and adults from Sekong province (an area of Laos with a low intensity of transmission) were tested in a 28-day, in-vivo study. Complete data were collected from 88 of the 102 subjects enrolled between October 1999 and September 2000. After genotypic analysis to distinguish recrudescing infections from re-infections, 35 (39.7%, with a 95% confidence interval of 29.5%-50.7%) of these 88 patients were considered treatment failures. These results seriously question the use of chloroquine as the first-line treatment for P. falciparum malaria in the study area.
dc.language.isoen
dc.publisherPublished by: Maney Publishing
dc.relation.urlhttp://www.maney.co.uk/journals/atmp
dc.rightsArchived on this site with the kind permission of Maney Publishingen_GB
dc.subject.meshAcute Disease
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAnimals
dc.subject.meshAntimalarials
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshChloroquine
dc.subject.meshFemale
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshLaos
dc.subject.meshMalaria, Falciparum
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPlasmodium falciparum
dc.subject.meshQuality Control
dc.subject.meshRecurrence
dc.subject.meshTreatment Failure
dc.subject.meshTreatment Outcome
dc.titleThe Efficacy of Chloroquine for the Treatment of Acute, Uncomplicated, Plasmodium Falciparum Malaria in Laos.
dc.contributor.departmentEpicentre, 8 rue Saint Sabin, 75011 Paris, France. jguthmann@epicentre.msf.org
dc.identifier.journalAnnals of Tropical Medicine and Parasitology
refterms.dateFOA2019-03-04T09:03:15Z
html.description.abstractTo assess the local efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria, children and adults from Sekong province (an area of Laos with a low intensity of transmission) were tested in a 28-day, in-vivo study. Complete data were collected from 88 of the 102 subjects enrolled between October 1999 and September 2000. After genotypic analysis to distinguish recrudescing infections from re-infections, 35 (39.7%, with a 95% confidence interval of 29.5%-50.7%) of these 88 patients were considered treatment failures. These results seriously question the use of chloroquine as the first-line treatment for P. falciparum malaria in the study area.


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