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    Jan 16, 2021
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    Efficacy of chloroquine, sulphadoxine-pyrimethamine and amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria in Kajo Keji county, Sudan.

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    Authors
    Stivanello, E
    Cavailler, P
    Cassano, F
    Omar, S A
    Kariuki, D
    Mwangi, J
    Piola, P
    Guthmann, J P
    Affiliation
    Médecins Sans Frontières, Geneva, Switzerland. elisasti@tin.it
    Issue Date
    2004-09
    
    Metadata
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    Journal
    Tropical Medicine & International Health
    Abstract
    To provide advice on the rational use of antimalarial drugs, Médecins Sans Frontières conducted a randomized, an open label efficacy study in Kajo Keji, an area of high transmission of malaria in southern Sudan. The efficacy of chloroquine (CQ), sulphadoxine-pyrimethamine (SP) and amodiaquine (AQ) were measured in a 28-day in vivo study, with results corrected by PCR genotyping. Of 2010 children screened, 115 children aged 6-59 months with uncomplicated Plasmodium falciparum malaria were randomized into each group to receive a supervised course of treatment. Of these, 114, 103 and 111 were analysed in the CQ, SP and AQ groups, respectively. The overall parasitological failure rates at day 28 were 93.9% [95% confidence interval (CI) 87.3-97.3] for CQ, 69.9% (95% CI 60.0-78.3) for SP, and 25.2% (95% CI 17.7-34.5) for AQ. These results provide important missing data on antimalarial drug efficacy in southern Sudan. They indicate that none of the drugs could be used in monotherapy and suggest that even in combination with artemisinin, cure rates might not be efficacious enough. We recommend a combination of artemether and lumefantrine as first-line treatment for uncomplicated P. falciparum malaria cases in Kajo Keji county.
    Publisher
    Wiley-Blackwell
    URI
    http://hdl.handle.net/10144/17280
    DOI
    10.1111/j.1365-3156.2004.01290.x
    PubMed ID
    15361110
    Additional Links
    http://www.blackwell-synergy.com/loi/tmi
    Language
    en
    ISSN
    1360-2276
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-3156.2004.01290.x
    Scopus Count
    Collections
    Malaria

    entitlement

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