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    Mar 03, 2021
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    Evaluation of a New Recombinant K39 Rapid Diagnostic Test for Sudanese Visceral Leishmaniasis.

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    Authors
    Ritmeijer, K
    Melaku, Y
    Mueller, M
    Kipngetich, S
    O'keeffe, C
    Davidson, R N
    Affiliation
    Médecins sans Frontières-Holland, Amsterdam, The Netherlands. koert.ritmeijer@amsterdam.msf.org
    Issue Date
    2006-01
    
    Metadata
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    Journal
    The American Journal of Tropical Medicine and Hygiene
    Abstract
    A new rK39 rapid diagnostic dipstick test (DiaMed-IT-Leish) was compared with aspiration and a direct agglutination test (DAT) for diagnosis of visceral leishmaniasis (VL) in 201 parasitologically confirmed cases, 133 endemic controls, and in 356 clinical suspects in disease-endemic and -epidemic areas in Sudan. The sensitivity of the rK39 test in parasitologically confirmed VL cases was 90%, whereas the specificity in disease-endemic controls was 99%. The sensitivity of the DAT was 98%. In clinically suspected cases, the sensitivity of the rK39 test was 81% and the specificity was 97%. When compared with the diagnostic protocol based on the DAT and aspiration used by Médecins sans Frontières in epidemic situations, the positive predictive value was 98%, and the negative predictive value was 71%. This rK39 rapid diagnostic test is suitable for screening as well as diagnosis of VL. Further diagnostic work-up of dipstick-negative patients with clinically suspected VL is important. The ease and convenience of the dipstick test will allow decentralization and improved access to care in disease-endemic areas in Sudan.
    Publisher
    Published by: American Society of Tropical Medicine and Hygiene
    URI
    http://hdl.handle.net/10144/17289
    PubMed ID
    16407349
    Additional Links
    http://www.ajtmh.org
    Language
    en
    ISSN
    0002-9637
    Collections
    Leishmaniasis/Kala Azar

    entitlement

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