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dc.contributor.authorRitmeijer, K
dc.contributor.authorMelaku, Y
dc.contributor.authorMueller, M
dc.contributor.authorKipngetich, S
dc.contributor.authorO'keeffe, C
dc.contributor.authorDavidson, R N
dc.date.accessioned2008-01-31T16:40:39Z
dc.date.available2008-01-31T16:40:39Z
dc.date.issued2006-01
dc.identifier.citationEvaluation of a New Recombinant K39 Rapid Diagnostic Test for Sudanese Visceral Leishmaniasis. 2006, 74 (1):76-80 Am. J. Trop. Med. Hyg.en
dc.identifier.issn0002-9637
dc.identifier.pmid16407349
dc.identifier.urihttp://hdl.handle.net/10144/17289
dc.description.abstractA new rK39 rapid diagnostic dipstick test (DiaMed-IT-Leish) was compared with aspiration and a direct agglutination test (DAT) for diagnosis of visceral leishmaniasis (VL) in 201 parasitologically confirmed cases, 133 endemic controls, and in 356 clinical suspects in disease-endemic and -epidemic areas in Sudan. The sensitivity of the rK39 test in parasitologically confirmed VL cases was 90%, whereas the specificity in disease-endemic controls was 99%. The sensitivity of the DAT was 98%. In clinically suspected cases, the sensitivity of the rK39 test was 81% and the specificity was 97%. When compared with the diagnostic protocol based on the DAT and aspiration used by Médecins sans Frontières in epidemic situations, the positive predictive value was 98%, and the negative predictive value was 71%. This rK39 rapid diagnostic test is suitable for screening as well as diagnosis of VL. Further diagnostic work-up of dipstick-negative patients with clinically suspected VL is important. The ease and convenience of the dipstick test will allow decentralization and improved access to care in disease-endemic areas in Sudan.
dc.language.isoenen
dc.publisherPublished by: American Society of Tropical Medicine and Hygiene
dc.relation.urlhttp://www.ajtmh.org
dc.rightsArchived on this site with the kind permission of the American Society of Tropical Medicine and Hygiene, www.astmh.orgen
dc.subject.meshAntigens, Protozoanen
dc.subject.meshHumansen
dc.subject.meshLeishmaniasis, Visceralen
dc.subject.meshPredictive Value of Testsen
dc.subject.meshProtozoan Proteinsen
dc.subject.meshReagent Kits, Diagnosticen
dc.subject.meshRecombinant Proteinsen
dc.subject.meshSensitivity and Specificityen
dc.subject.meshSudanen
dc.subject.meshTime Factorsen
dc.titleEvaluation of a New Recombinant K39 Rapid Diagnostic Test for Sudanese Visceral Leishmaniasis.en
dc.contributor.departmentMédecins sans Frontières-Holland, Amsterdam, The Netherlands. koert.ritmeijer@amsterdam.msf.orgen
dc.identifier.journalThe American Journal of Tropical Medicine and Hygieneen
refterms.dateFOA2019-03-04T09:04:00Z
html.description.abstractA new rK39 rapid diagnostic dipstick test (DiaMed-IT-Leish) was compared with aspiration and a direct agglutination test (DAT) for diagnosis of visceral leishmaniasis (VL) in 201 parasitologically confirmed cases, 133 endemic controls, and in 356 clinical suspects in disease-endemic and -epidemic areas in Sudan. The sensitivity of the rK39 test in parasitologically confirmed VL cases was 90%, whereas the specificity in disease-endemic controls was 99%. The sensitivity of the DAT was 98%. In clinically suspected cases, the sensitivity of the rK39 test was 81% and the specificity was 97%. When compared with the diagnostic protocol based on the DAT and aspiration used by Médecins sans Frontières in epidemic situations, the positive predictive value was 98%, and the negative predictive value was 71%. This rK39 rapid diagnostic test is suitable for screening as well as diagnosis of VL. Further diagnostic work-up of dipstick-negative patients with clinically suspected VL is important. The ease and convenience of the dipstick test will allow decentralization and improved access to care in disease-endemic areas in Sudan.


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