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    Jan 16, 2021
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    Liposomal Amphotericin B (AmBisome) in the Treatment of Complicated Kala-Azar Under Field Conditions.

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    Authors
    Seaman, J
    Boer, C
    Wilkinson, R
    de Jong, J
    de Wilde, E
    Sondorp, H
    Davidson, R N
    Affiliation
    Medecins Sans Frontieres Holland, The Netherlands.
    Issue Date
    1995-07
    
    Metadata
    Show full item record
    Journal
    Clinical Infectious Diseases
    Abstract
    An open trial of liposomal amphotericin B (AmBisome [L-AmB]; Vestar, San Dimas, CA) for treatment of complicated visceral leishmaniasis was performed in Sudan. Forty-nine patients were treated, and there were six deaths (12% mortality); these were not attributed to therapy. Thirty-seven patients were selected for the trial because of (1) relapse after treatment with a combination of pentavalent antimony (Sbv) and aminosidine, (2) incomplete parasitological response to Sbv and aminosidine, or (3) severe illness. Drug regimen 1 (3 doses of 3-5 mg/kg, on days 0, 3, and 10) cured 8 (50%) of 16 patients; regimen 2 (6 doses of 3-5 mg/kg, on days 0, 3, 6, 8, 10, and 13) cured 14 (88%) of 16. For four of 10 partial responders, "rescue" therapy with L-AmB alone (3 mg/kg daily for 10 days) resulted in cure. Twelve less-unwell patients received regimen 3 (4 doses of 4-5 mg/kg, on days 0, 2, 5, and 7); seven of 11 patients evaluated (64%) were cured. The optimal regimen of L-AmB in these circumstances is administration of 4 mg/kg on days 0, 3, 6, 8, 10, and 13.
    Publisher
    Published by: Infectious Diseases Society of America
    URI
    http://hdl.handle.net/10144/17671
    PubMed ID
    7578729
    Additional Links
    http://www.journals.uchicago.edu/page/cid/brief.html
    Language
    en
    ISSN
    1058-4838
    Collections
    Leishmaniasis/Kala Azar

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