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    Jan 17, 2021
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    High Efficacy of Two Artemisinin-Based Combinations (Artesunate + Amodiaquine and Artemether + Lumefantrine) in Caala, Central Angola.

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    Authors
    Guthmann, J P
    Cohuet, S
    Rigutto, C
    Fortes, F
    Saraiva, N
    Kiguli, J
    Kyomuhendo, J
    Francis, M
    Noël, F
    Mulemba, M
    Balkan, S
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    Affiliation
    Epicentre, Paris, France; Médecins Sans Frontières, Paris, France. jguthmann@epicentre.msf.org
    Issue Date
    2006-07
    
    Metadata
    Show full item record
    Journal
    American Journal of Tropical Medicine and Hygiene
    Abstract
    In April 2004, 137 children 6-59 months of age with uncomplicated Plasmodium falciparum (Pf) malaria (Caala, Central Angola) were randomized to receive either artemether-lumefantrine (Coartem) or artesunate + amodiaquine (ASAQ). After 28 days of follow-up, there were 2/61 (3.2%) recurrent parasitemias in the Coartem group and 4/64 (6.2%) in the ASAQ group (P = 0.72), all classified as re-infections after PCR genotyping (cure rate = 100% [95%CI: 94-100] in both groups). Only one patient (ASAQ group) had gametocytes on day 28 versus five (Coartem) and three (ASAQ) at baseline. Compared with baseline, anemia was significantly improved after 28 days of follow-up in both groups (Coartem: from 54.1% to 13.4%; ASAQ: from 53.1% to 15.9%). Our findings are in favor of a high efficacy of both combinations in Caala. Now that Coartem has been chosen as the new first-line anti-malarial, the challenge is to insure that this drug is available and adequately used.
    Publisher
    Published by: American Society of Tropical Medicine and Hygiene
    URI
    http://hdl.handle.net/10144/17676
    PubMed ID
    16837721
    Additional Links
    http://www.ajtmh.org
    Language
    en
    ISSN
    0002-9637
    Collections
    Malaria

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