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dc.contributor.authorDepoortere, E*
dc.contributor.authorKavle, J*
dc.contributor.authorKeus, K*
dc.contributor.authorZeller, H*
dc.contributor.authorMurri, S*
dc.contributor.authorLegros, D*
dc.date.accessioned2008-02-07T16:34:53Z
dc.date.available2008-02-07T16:34:53Z
dc.date.issued2004-06
dc.identifier.citationOutbreak of West Nile virus causing severe neurological involvement in children, Nuba Mountains, Sudan, 2002. 2004, 9 (6):730-6 Trop. Med. Int. Healthen
dc.identifier.issn1360-2276
dc.identifier.pmid15189465
dc.identifier.doi10.1111/j.1365-3156.2004.01253.x
dc.identifier.urihttp://hdl.handle.net/10144/17724
dc.description.abstractAn atypical outbreak of West Nile virus (WNV) occurred in Ngorban County, South Kordophan, Sudan, from May to August 2002. We investigated the epidemic and conducted a case-control study in the village of Limon. Blood samples were obtained for cases and controls. Patients with obvious sequelae underwent cerebrospinal fluid (CSF) sampling as well. We used enzyme-linked immunosorbent assay (ELISA) and neutralization tests for laboratory diagnosis and identified 31 cases with encephalitis, four of whom died. Median age was 36 months. Bivariate analysis did not reveal any significant association with the risk factors investigated. Laboratory analysis confirmed presence of IgM antibodies caused by WNV in eight of 13 cases, indicative of recent viral infection. The unique aspects of the WNW outbreak in Sudan, i.e. disease occurrence solely among children and the clinical domination of encephalitis, involving severe neurological sequelae, demonstrate the continuing evolution of WNV virulence. The spread of such a virus to other countries or continents cannot be excluded.
dc.language.isoenen
dc.publisherWiley-Blackwell
dc.relation.urlhttp://www.blackwell-synergy.com/loi/tmi
dc.rightsArchived on this site with the kind permission of Wiley-Blackwellen
dc.subject.meshCase-Control Studiesen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshDisease Outbreaksen
dc.subject.meshEncephalitisen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshMaleen
dc.subject.meshRetrospective Studiesen
dc.subject.meshRisk Factorsen
dc.subject.meshRural Populationen
dc.subject.meshSudanen
dc.subject.meshWest Nile Feveren
dc.titleOutbreak of West Nile virus causing severe neurological involvement in children, Nuba Mountains, Sudan, 2002.en
dc.contributor.departmentEpicentre, Paris, France. evelyn.depoortere@msf.been
dc.identifier.journalTropical Medicine & International Healthen
refterms.dateFOA2019-03-04T09:11:38Z
html.description.abstractAn atypical outbreak of West Nile virus (WNV) occurred in Ngorban County, South Kordophan, Sudan, from May to August 2002. We investigated the epidemic and conducted a case-control study in the village of Limon. Blood samples were obtained for cases and controls. Patients with obvious sequelae underwent cerebrospinal fluid (CSF) sampling as well. We used enzyme-linked immunosorbent assay (ELISA) and neutralization tests for laboratory diagnosis and identified 31 cases with encephalitis, four of whom died. Median age was 36 months. Bivariate analysis did not reveal any significant association with the risk factors investigated. Laboratory analysis confirmed presence of IgM antibodies caused by WNV in eight of 13 cases, indicative of recent viral infection. The unique aspects of the WNW outbreak in Sudan, i.e. disease occurrence solely among children and the clinical domination of encephalitis, involving severe neurological sequelae, demonstrate the continuing evolution of WNV virulence. The spread of such a virus to other countries or continents cannot be excluded.


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