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    Jan 23, 2021
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    A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia.

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    Authors
    Janssens, B
    Van Herp, M
    Goubert, L
    Chan, S
    Uong, S
    Nong, S
    Socheat, D
    Brockman, A
    Ashley, E A
    Van Damme, W
    Affiliation
    Médecins Sans Frontières, Phnom Penh, Cambodia. b.janssens@bigfoot.com
    Issue Date
    2007-02
    
    Metadata
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    Journal
    Tropical Medicine & International Health
    Abstract
    OBJECTIVES: To compare the efficacy and tolerability of dihydroartemisinin-piperaquine (DHA-PQP) with that of a 3-day regimen of mefloquine and artesunate (MAS3) for the treatment of uncomplicated falciparum malaria in Cambodia. METHOD: Randomized open-label non-inferiority study over 64 days. RESULTS: Four hundred and sixty-four patients were included in the study. The polymerase chain reaction genotyping-adjusted cure rates on day 63 were 97.5% (95% confidence interval, CI, 93.8-99.3) for DHA-PQP and 97.5% (95% CI, 93.8-99.3) for MAS3, P = 1. There were no serious adverse events, but significantly more episodes of vomiting (P = 0.03), dizziness (P = 0.002), palpitations (P = 0.04), and sleep disorders (P = 0.03) reported in the MAS3 treatment group, consistent with the side-effect profile of mefloquine. CONCLUSIONS: DHA-PQP was as efficacious as MAS3, but much better tolerated, making it more appropriate for use in a routine programme setting. This highly efficacious, safe and more affordable fixed-dose combination could become the treatment of choice for Plasmodium falciparum malaria in Cambodia.
    Publisher
    Wiley-Blackwell
    URI
    http://hdl.handle.net/10144/17743
    DOI
    10.1111/j.1365-3156.2006.01786.x
    PubMed ID
    17300633
    Additional Links
    http://www.blackwell-synergy.com/loi/tmi
    Language
    en
    ISSN
    1360-2276
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-3156.2006.01786.x
    Scopus Count
    Collections
    Malaria

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