Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone.
AffiliationDivision of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway. email@example.com
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AbstractIn November 1999, a Médecins Sans Frontières team based in the southeastern part of Sierra Leone reported an increased number of cases of bloody diarrhoea. Shigella dysenteriae serotype 1 (Sd1) was isolated in the early cases. A total of 4218 cases of dysentery were reported in Kenema district from December, 1999, to March, 2000. The overall attack rate was 7.5%. The attack rate was higher among children younger than 5 years than in the rest of the population (11.2% vs 6.8%; relative risk=1.6; 95% CI 1.5-1.8). The case fatality was 3.1%, also higher for children younger than 5 years (6.1% vs 2.1%; relative risk=2.9; 95% CI 2.1-4.1]). Among 583 patients regarded at increased risk of death who were treated with ciprofloxacin in isolation centres, case fatality was 0.9%. A 5-day ciprofloxacin regimen, targeted to the most severe cases of bloody diarrhoea, was highly effective. This is the first time a large outbreak caused by Sd1 has been reported in west Africa.
- Case management of a multidrug-resistant Shigella dysenteriae serotype 1 outbreak in a crisis context in Sierra Leone, 1999-2000.
- Authors: Guerin PJ, Brasher C, Baron E, Mic D, Grimont F, Ryan M, Aavitsland P, Legros D
- Issue date: 2004 Nov
- [Ciprofloxacin in the treatment of dysentery caused by type 1 Shigella dysenteriae during an epidemic in Rwandan refugees in Goma in 1994].
- Authors: Laureillard D, Paquet C, Malvy D
- Issue date: 1998 Jul-Aug
- [An outbreak of Shigella dysenteriae type 1 dysentery in a refugee camp in Rwanda].
- Authors: Paquet C, Leborgne P, Sasse A, Varaine F
- Issue date: 1995 May-Jun
- Emergence of nalidixic acid resistant Shigella dysenteriae type 1 in Thailand: an outbreak associated with consumption of a coconut milk dessert.
- Authors: Hoge CW, Bodhidatta L, Tungtaem C, Echeverria P
- Issue date: 1995 Dec
- Risk factors for death in hospitalized dysentery patients in Rwanda.
- Authors: Legros D, Paquet C, Dorlencourt F, Saoult E
- Issue date: 1999 Jun