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    Apr 10, 2021
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    Short communication: antituberculosis drug-induced hepatotoxicity is unexpectedly low in HIV-infected pulmonary tuberculosis patients in Malawi.

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    Authors
    Tostmann, A
    Boeree, M J
    Harries, A D
    Sauvageot, D
    Banda, H T
    Zijlstra, E E
    Affiliation
    Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre and University Lung Centre Dekkerswald, Nijmegen, The Netherlands. A.Tostmann@ulc.umcn.nl
    Issue Date
    2007-07
    
    Metadata
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    Journal
    Tropical Medicine & International Health
    Abstract
    The proportion of patients with antituberculosis drug-induced hepatotoxicity (ATDH) was unexpectedly low during a trial on cotrimoxazole prophylaxis in Malawian HIV-positive pulmonary tuberculosis patients. About 2% of the patients developed grade 2 or 3 hepatotoxicity during tuberculosis (TB) treatment, according to WHO definitions. Data on ATDH in sub-Saharan Africa are limited. Although the numbers are not very strong, our trial and other papers suggest that ATDH is uncommon in this region. These findings are encouraging in that hepatotoxicity may cause less problem than expected, especially in the light of combined HIV/TB treatment, where drug toxicity is a major cause of treatment interruption.
    URI
    http://hdl.handle.net/10144/18241
    DOI
    10.1111/j.1365-3156.2007.01871.x
    PubMed ID
    17596252
    Additional Links
    http://www.blackwell-synergy.com/loi/tmi
    Language
    en
    ISSN
    1360-2276
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-3156.2007.01871.x
    Scopus Count
    Collections
    TB

    entitlement

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