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    Jan 19, 2021
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    Successful Miltefosine Treatment of Post-Kala-Azar Dermal Leishmaniasis Occurring During Antiretroviral Therapy.

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    Authors
    Belay, A D
    Asafa, Y
    Mesure, J
    Davidson, R N N
    Affiliation
    Médecins Sans Frontières - Netherlands, Plantage Middenlaan 14, P.O. Box 10014, 1001 EA Amsterdam, The Netherlands.
    Issue Date
    2006-04
    
    Metadata
    Show full item record
    Journal
    Annals of Tropical Medicine and Parasitology
    Abstract
    The first two patients to be treated with miltefosine for post-kala-azar dermal leishmaniasis (PKDL) are reported. One was a 26-year-old Ethiopian man who had been treated with sodium stibogluconate, for relapsing visceral leishmaniasis (VL), four times between August 2002 and March 2004. In January 2004 this patient was found to be seropositive for HIV and began antiretroviral treatment with stavudine, lamivudine and nevirapine. Five months later he developed clinical PKDL, with extensive cutaneous, conjunctival and oral mucosal involvement. The second patient was a 42-year-old Ethiopian man who was treated for relapsing VL in November 2003. He too was subsequently found to be seropositive for HIV and was treated with stavudine, lamivudine and nevirapine from May 2004. He developed a nodular rash of PKDL over his face and upper body 2 weeks after starting the antiretroviral therapy. Treatment of both patients with oral miltefosine, at 100 mg/day for 28 days, led to the complete regression of their PKDL lesions. When checked 3-6 months after the end of the miltesofine treatment, neither patient showed any signs of VL, PKDL or other HIV-associated disease.
    Publisher
    Published by: Maney Publishing
    URI
    http://hdl.handle.net/10144/18245
    DOI
    10.1179/136485906X91440
    PubMed ID
    16630379
    Additional Links
    http://www.maney.co.uk/journals/atmp
    Language
    en
    ISSN
    0003-4983
    ae974a485f413a2113503eed53cd6c53
    10.1179/136485906X91440
    Scopus Count
    Collections
    Leishmaniasis/Kala Azar

    entitlement

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