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dc.contributor.authorOchong, E
dc.contributor.authorvan den Broek, I
dc.contributor.authorKeus, K
dc.contributor.authorNzila, A
dc.date.accessioned2008-02-14T11:03:25Z
dc.date.available2008-02-14T11:03:25Z
dc.date.issued2003-08
dc.identifier.citationShort Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan. 2003, 69 (2):184-7 Am. J. Trop. Med. Hyg.en
dc.identifier.issn0002-9637
dc.identifier.pmid13677373
dc.identifier.urihttp://hdl.handle.net/10144/18255
dc.description.abstractAmodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected. Although amodiaquine is more potent than chloroquine, its effectiveness is reduced in areas where chloroquine resistance is high. We report an association of the P. falciparum chloroquine resistance transporter (pfcrt) gene and the P. falciparum multiple drug resistance 1 (pfmdr1) gene, two chloroquine resistance markers, with chloroquine and amodiaquine efficacy in vivo in southern Sudan. The data show that the allele of the pfcrt gene with a lysine to threonine change at codon 76 is strongly associated with both chloroquine and amodiaquine resistance. No such association was observed with the pfmdr1 gene.
dc.language.isoenen
dc.publisherPublished by: American Society of Tropical Medicine and Hygiene
dc.relation.urlhttp://www.ajtmh.org
dc.rightsArchived on this site with the kind permission of the American Society of Tropical Medicine and Hygiene, www.astmh.orgen
dc.subject.meshATP-Binding Cassette Transportersen
dc.subject.meshAllelesen
dc.subject.meshAmodiaquineen
dc.subject.meshAnimalsen
dc.subject.meshAntimalarialsen
dc.subject.meshChloroquineen
dc.subject.meshDrug Resistance, Multipleen
dc.subject.meshHumansen
dc.subject.meshMalaria, Falciparumen
dc.subject.meshMembrane Proteinsen
dc.subject.meshMembrane Transport Proteinsen
dc.subject.meshParasitic Sensitivity Testsen
dc.subject.meshPlasmodium falciparumen
dc.subject.meshProtozoan Proteinsen
dc.subject.meshSudanen
dc.subject.meshVariation (Genetics)en
dc.titleShort Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan.en
dc.contributor.departmentKenya Medical Research Institute, Wellcome Trust Collaborative Program, Médecins sans Frontières-Holland, South Sudan Section, Nairobi, Kenya.en
dc.identifier.journalThe American Journal of Tropical Medicine and Hygieneen
refterms.dateFOA2019-03-04T09:18:33Z
html.description.abstractAmodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected. Although amodiaquine is more potent than chloroquine, its effectiveness is reduced in areas where chloroquine resistance is high. We report an association of the P. falciparum chloroquine resistance transporter (pfcrt) gene and the P. falciparum multiple drug resistance 1 (pfmdr1) gene, two chloroquine resistance markers, with chloroquine and amodiaquine efficacy in vivo in southern Sudan. The data show that the allele of the pfcrt gene with a lysine to threonine change at codon 76 is strongly associated with both chloroquine and amodiaquine resistance. No such association was observed with the pfmdr1 gene.


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