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    Apr 14, 2021
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    Utility of Lymph Node Aspiration in the Diagnosis of Visceral Leishmaniasis in Sudan.

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    Authors
    Babiker, Z O E
    Davidson, R N N
    Mazinda, C
    Kipngetich, S
    Ritmeijer, K
    Affiliation
    Médecins Sans Frontières-Holland, Amsterdam, The Netherlands. zahir_babiker@yahoo.co.uk
    Issue Date
    2007-04
    
    Metadata
    Show full item record
    Journal
    The American Journal of Tropical Medicine and Hygiene
    Abstract
    We evaluated lymph node aspiration (LNA) as a simple diagnostic procedure for visceral leishmaniasis (VL). Lymph node aspiration was compared with the direct agglutination test (DAT) using a diagnostic titer > or = 1:6,400 in 7,880 suspected VL patients in eastern Sudan. Compared with DAT, LNA had a sensitivity of 65.1% (95% confidence interval = 63.5-66.6%). Parasite density in LNA correlated strongly with DAT titers (P < 0.0001), and low parasite density accounted for 78.1% of positive LNA results with DAT titers < 1:6,400 (n = 782). Risk factors predictive of a positive LNA result were an age of 1-29 years, male sex, a hemoglobin level < 10.0 g/dL, a DAT titer > or = 1:800, and a location with a higher prevalence of VL. Lymph node and splenic aspirations were similarly accurate as tests of cure after treatment of 50 VL patients in southern Sudan. Pre-treatment LNA results were negative in 20 cases of severe post kala-azar dermal leishmaniasis.
    Publisher
    Published by: American Society of Tropical Medicine and Hygiene
    URI
    http://hdl.handle.net/10144/18275
    PubMed ID
    17426171
    Additional Links
    http://www.ajtmh.org
    Language
    en
    ISSN
    0002-9637
    Collections
    Leishmaniasis/Kala Azar

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