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    Jan 26, 2021
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    Validity, reliability and ease of use in the field of five rapid tests for the diagnosis of Plasmodium falciparum malaria in Uganda.

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    Authors
    Guthmann, J P
    Ruiz, A
    Priotto, G
    Kiguli, J
    Bonte, L
    Legros, D
    Affiliation
    Epicentre, 4 rue Saint Sabin, 75011 Paris, France. jguthmann@epicentre.msf.org
    Issue Date
    2008-02-14T11:38:37Z
    
    Metadata
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    Journal
    Transactions of the Royal Society of Tropical Medicine and Hygiene
    Abstract
    A study was conducted to measure the overall performance of several rapid diagnostic tests for Plasmodium falciparum infection, in order to select the most appropriate test to be used in the field. A total of 742 patients attending the out-patient department of Mbarara Hospital with a clinical suspicion of malaria were included in the study. For each patient, a thick/thin film and 5 rapid tests based on the detection of histidine-rich protein II (HRP-II) (Paracheck Pf dipstick and device, ParaHIT f, Malaria Rapid and BIO P.F.) were performed. Outcomes were validity, inter-reader reliability and 'ease of use in the field', measured by both the general characteristics of the test and by the opinion of the readers. About half (57%) of the patients were positive for P. falciparum. The Paracheck Pf (dipstick and device) was considered as the most appropriate for the use in the field, being sensitive (97%), moderately specific (88%), reliable (kappa coefficient = 0.97), easy to use and cheap (about US$ 0.5/test). The ParaHIT f represented a good alternative.
    Publisher
    Elsevier
    URI
    http://hdl.handle.net/10144/18277
    PubMed ID
    12174772
    Additional Links
    http://www.sciencedirect.com/science/journal/00359203
    Language
    en
    ISSN
    0035-9203
    Collections
    Malaria

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