WHO Clinical Staging of HIV Infection and Disease, Tuberculosis and Eligibility for Antiretroviral Treatment: Relationship to CD4 Lymphocyte Counts.
Authors
Teck, RAscurra, O
Gomani, P
Manzi, M
Pasulani, O
Kusamale, J
Salaniponi, F M L
Humblet, P
Nunn, P
Scano, F
Harries, A D
Zachariah, R
Affiliation
Médecins sans Frontières-Luxembourg, Thyolo, Malawi.Issue Date
2005-03
Metadata
Show full item recordAbstract
SETTING: Thyolo district, Malawi. OBJECTIVES: To determine in HIV-positive individuals aged over 13 years CD4 lymphocyte counts in patients classified as WHO Clinical Stage III and IV and patients with active and previous tuberculosis (TB). DESIGN: Cross-sectional study. METHODS: CD4 lymphocyte counts were determined in all consecutive HIV-positive individuals presenting to the antiretroviral clinic in WHO Stage III and IV. RESULTS: A CD4 lymphocyte count of < or = 350 cells/microl was found in 413 (90%) of 457 individuals in WHO Stage III and IV, 96% of 77 individuals with active TB, 92% of 65 individuals with a history of pulmonary TB (PTB) in the last year, 91% of 89 individuals with a previous history of PTB beyond 1 year, 81% of 32 individuals with a previous history of extra-pulmonary TB, 93% of 107 individuals with active or past TB with another HIV-related disease and 89% of 158 individuals with active or past TB without another HIV-related disease. CONCLUSIONS: In our setting, nine of 10 HIV-positive individuals presenting in WHO Stage III and IV and with active or previous TB have CD4 counts of < or = 350 cells/microl. It would thus be reasonable, in this or similar settings where CD4 counts are unavailable for clinical management, for all such patients to be considered eligible for antiretroviral therapy.PubMed ID
15786887Additional Links
http://www.ingentaconnect.com/content/iuatld/ijtldLanguage
enISSN
1027-3719Collections
Related articles
- CD4 validation for the World Health Organization classification and clinical staging of HIV/AIDS in a developing country.
- Authors: Edathodu J, Ali B, Alrajhi AA
- Issue date: 2009 Mar
- Targeting CD4 testing to a clinical subgroup of patients could limit unnecessary CD4 measurements, premature antiretroviral treatment and costs in Thyolo District, Malawi.
- Authors: Zachariah R, Teck R, Ascurra O, Humblet P, Harries AD
- Issue date: 2006 Jan
- Characteristics of HIV-infected tuberculosis patients in Thailand.
- Authors: Mankatittham W, Likanonsakul S, Thawornwan U, Kongsanan P, Kittikraisak W, Burapat C, Akksilp S, Sattayawuthipong W, Srinak C, Nateniyom S, Tasaneeyapan T, Varma JK
- Issue date: 2009 Jan
- Should absolute lymphocyte count be used as a surrogate marker for CD4+ count in patients with HIV/AIDS?
- Authors: Jibrin YB, Yusuph H, Garbati MA, Gashau W, Abja UM
- Issue date: 2006 Mar
- CD4 cell count recovery in HIV/TB co-infected patients versus TB uninfected HIV patients.
- Authors: Wanchu A, Kuttiatt VS, Sharma A, Singh S, Varma S
- Issue date: 2010 Oct-Dec